ReviewCurrent neurology and neuroscience reports2019
Sleep-Disordered Breathing and Idiopathic Normal-Pressure Hydrocephalus: Recent Pathophysiological Advances.
Review in Current neurology and neuroscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06857136 (The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Associations between obstructive sleep apnea and Alzheimer's disease-related biomarkers (amyloid-β and tau) in blood and cerebrospinal fluid: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review.Frontiers in neuroscience · 2025Pooled it
- From the past to the present: evolving theories in the pathophysiology of normal pressure hydrocephalus.Journal of neurology, neurosurgery, and psychiatry · 2026Review
- Alterations of Glymphatic System Before and After Shunt Surgery in Patients With Idiopathic Normal Pressure Hydrocephalus: A Longitudinal Study.European journal of neurology · 2025Article
- Review
- Clinical correlates of obstructive sleep apnoea in idiopathic normal pressure hydrocephalus.European journal of neurology · 2024Observational
- Sleep Disordered Breathing and Neurocognitive Disorders.Journal of clinical medicine · 2024Review
- [Causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus: a two-sample bidirectional Mendelian randomization study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Association between vascular risk factors and idiopathic normal pressure hydrocephalus: a Mendelian randomization study.Journal of neurology · 2023Article
- Impaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction.Journal of neurology · 2023Article
- Comparison of cerebrospinal fluid space between probable normal pressure hydrocephalus and Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Assessment of factors influencing glymphatic activity and implications for clinical medicine.Frontiers in neurology · 2023Review
- Article
- Deep breathing couples CSF and venous flow dynamics.Scientific reports · 2022Article
- Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders.Frontiers in aging neuroscience · 2022Review
- Physical Capacity and Activity in Patients With Idiopathic Normal Pressure Hydrocephalus.Frontiers in neurology · 2022Article
- Aquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephalus.International journal of molecular sciences · 2021Article
- Sleep-Based Interventions in Alzheimer's Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The Need for Head Space: Brachycephaly and Cerebrospinal Fluid Disorders.Life (Basel, Switzerland) · 2021Review
- Diffuse glioma manifesting as normal pressure hydrocephalus: A potential pitfall in diagnosis-a case report.Cerebral circulation - cognition and behavior · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewIdiopathic normal-pressure hydrocephalus (iNPH) is characterized clinically by ventriculomegaly, abnormal gait, falls, incontinence, and cognitive decline. This article reviews recent advances in the pathophysiology of iNPH concerning sleep-disordered breathing (SDB) and glymphatic circulation during deep sleep. RECENT
findingsThe authors found iNPH frequently associated with obstructive sleep apnea (OSA). A critical factor in iNPH is intracranial venous hypertension delaying drainage of cerebrospinal fluid (CSF) into the cerebral venous sinuses. CSF-venous blood circulates in the jugular veins and finally drains into the heart. During SDB, repeated reflex attempts to breathe induce strong respiratory efforts against a closed glottis thereby increasing the negative intrathoracic pressure. This causes atrial distortion and decreases venous return to the heart resulting in retrograde intracranial venous hypertension. Additionally, repeated awakenings from OSA impede sleep-associated circulation of interstitial CSF into the glymphatic circulation contributing to hydrocephalus. Sleep has become a critical element in the cognitive changes of aging including iNPH.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.