Trial reportIntensive care medicine2019
Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial.
Trial report in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Strategies to Maximize the Benefits of Evidence-Based Enteral Nutrition: A Narrative Review.Nutrients · 2025Pooled it
- Small peptide formulas versus standard polymeric formulas in critically ill patients with acute gastrointestinal injury: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial.Critical care (London, England) · 2023Trial
- Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial.Intensive care medicine · 2022Trial
- Effect of dietitian-guided nutritional support on intensive care units length of stay and nutritional risk in critically Ill patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Article
- A New Perspective on Overfeeding in the Intensive Care Unit (ICU): Challenges, Dangers and Prevention Methods.Life (Basel, Switzerland) · 2025Review
- Association between early enteral nutrition and 28-Day mortality in mechanically ventilated patients with sepsis: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Observational
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- Nine Myths about Enteral Feeding in Critically Ill Adults: An Expert Perspective.Advances in nutrition (Bethesda, Md.) · 2025Review
- [Nutrition (therapy) in gastrointestinal failure].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China.Journal of intensive medicine · 2024Article
- Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case-control study.Annals of intensive care · 2024Article
- Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options.Journal of clinical medicine · 2023Review
- A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice.Critical care (London, England) · 2021Review
- Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence.World journal of gastroenterology · 2021Review
- Focus on gastrointestinal system in critically ill patients.Intensive care medicine · 2020Article
- Early Enteral Nutrition Preserves Intestinal Barrier Function through Reducing the Formation of Neutrophil Extracellular Traps (NETs) in Critically Ill Surgical Patients.Oxidative medicine and cellular longevity · 2020Article
- Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases.Critical care (London, England) · 2019Review
- Dose of enteral nutrition and enterocyte biomarker: a circular link?Intensive care medicine · 2019Article
- Causal inference in secondary analysis of a randomized controlled trial.Intensive care medicine · 2019Article
Corrections and comments
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Authors and funding
16 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe effects of the route of nutrition on the gut mucosa of patients with shock are unclear. Plasma citrulline concentration is a marker of enterocyte mass, and plasma intestinal fatty acid binding protein (I-FABP) concentration is a marker of enterocyte damage. We aimed to study the effect of the route of nutrition on plasma citrulline concentration measured at day 3 of nutrition. MATERIALS AND
methodsAncillary study of the NUTRIREA-2 trial. Ventilated adults with shock were randomly assigned to receive enteral or parenteral nutrition. Enterocyte biomarkers were measured at baseline, day 3, and day 8 of nutrition.
resultA total of 165 patients from 13 French ICUs were included in the study: 85 patients in the enteral group and 80 patients in the parenteral group. At baseline, plasma citrulline was low without difference between groups (12.2 µmol L
conclusionPlasma citrulline concentration was higher after 3 days of enteral nutrition than after 3 days of parenteral nutrition. This result raises the question of the possibility that enteral nutrition is associated with a more rapid restoration of enterocyte mass than parenteral nutrition.
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