SynthesisIntensive care medicine2019
Changes in critically ill cancer patients' short-term outcome over the last decades: results of systematic review with meta-analysis on individual data.
Synthesis in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Impact of intensive care unit admission on the resumption of treatment in patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Temporal trends and prognostic factors in critically ill adult patients with acute leukemia: an individual participant data meta-analysis.Intensive care medicine · 2026Pooled it
- Early mortality in patients with acute promyelocytic leukemia: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Mortality in Cancer Patients With COVID-19 Who Are Admitted to an ICU or Who Have Severe COVID-19: A Systematic Review and Meta-Analysis.JCO global oncology · 2021Pooled it
- Sarcopenia as a predictor of mortality among the critically ill in an intensive care unit: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- Temporal Heterogeneity of Factors Associated with Intra-ICU Mortality: A Formal Interaction Analysis of the Multi-Centre Silesian ICU Registry (2010-2020).Journal of clinical medicine · 2026Article
- Intensivist and Hematologist Perceptions of Prognosis of Critically Ill Patients with Hematologic Malignancies.Journal of intensive care medicine · 2026Article
- Is mortality truly higher for oncology patients admitted to intensive care units? A matched cohort observational study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Observational
- Characterization and outcomes of severe complications after autologous hematopoietic stem-cell transplantation: a retrospective multicenter study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Immune interplay between sepsis and haematological malignancies.Intensive care medicine experimental · 2026Review
- Article
- Factors associated with treatment resumption and long-term outcomes after ICU discharge in patients with hematological malignancies.Annals of intensive care · 2026Article
- Outcomes of Cancer Patients Requiring Non-elective Medical Admission to the Intensive Care Unit of a Tertiary Care Center in India: A 5-year Retrospective Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Survival and quality-adjusted life years in critically ill cancer patients: analysis on the fifth day of intensive care unit stay.Critical care science · 2026Article
- Life-threatening immune-related adverse events in the intensive care unit: a narrative review.Intensive care medicine · 2025Review
- Article
- Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study.Intensive care medicine · 2025Observational
- Acute Respiratory Distress Syndrome Phenotypes After Stem Cell Transplantation: A Latent Class Analysis.Critical care explorations · 2025Article
- Diagnostic performance of Pneumonia multiplex PCR in critically ill immunocompromised patients.Critical care (London, England) · 2025Article
- Contemporary review of critical illness following allogeneic hematopoietic stem cell transplant in adults.Intensive care medicine · 2025Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe number of averted deaths due to therapeutic advances in oncology and hematology is substantial and increasing. Survival of critically ill cancer patients has also improved during the last 2 decades. However, these data stem predominantly from unadjusted analyses. The aim of this study was to assess the impact of ICU admission year on short-term survival of critically ill cancer patients, with special attention on those with neutropenia.
methodsSystematic review and meta-analysis of individual data according to the guidelines of meta-analysis of observational studies in epidemiology. DATASOURCE: Pubmed and Cochrane databases. ELIGIBILITY CRITERIA: Adult studies published in English between May 2005 and May 2015.
resultsOverall, 7354 patients were included among whom 1666 presented with neutropenia at ICU admission. Median ICU admission year was 2007 (IQR 2004-2010; range 1994-2012) and median number of admissions per year was 693 (IQR 450-1007). Overall mortality was 47.7%. ICU admission year was associated with a progressive decrease in hospital mortality (OR per year 0.94; 95% CI 0.93-0.95). After adjustment for confounders, year of ICU admission was independently associated with hospital mortality (OR for hospital mortality per year: 0.96; 95% CI 0.95-0.97). The association was also seen in patients with neutropenia but not in allogeneic stem cell transplant recipients.
conclusionAfter adjustment for patient characteristics, severity of illness and clustering, hospital mortality decreased steadily over time in critically ill oncology and hematology patients except for allogeneic stem cell transplant recipients.
Indexed as
Identifiers
31143998What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.