Evidence map›Paper›PMID 31143845›Full record

ReviewTranslational gastroenterology and hepatology2019

Adjuvant therapy with imatinib in gastrointestinal stromal tumors (GISTs)-review and perspectives.

Marie Laurent, Mehdi Brahmi, Armelle Dufresne, Pierre Meeus, Marie Karanian, Isabelle Ray-Coquard, Jean-Yves Blay

Open access · diamondAbstract readReview
In one paragraph

Review in Translational gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Duration-dependent effects of adjuvant imatinib on recurrence-free and overall survival after resection of gastrointestinal stromal tumors: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Article
  4. Article
  5. Surgical treatment of gastrointestinal stromal tumors.Journal of medicine and life · 2026
    Review
  6. The R.O.A.D. to precision medicine.NPJ digital medicine · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marie LaurentDepartment of Medical Oncology, Centre Leon Berard, Lyon, France.
Mehdi BrahmiDepartment of Medical Oncology, Centre Leon Berard, Lyon, France.
Armelle DufresneDepartment of Medical Oncology, Centre Leon Berard, Lyon, France.
Pierre MeeusDepartment of Medical Oncology, Centre Leon Berard, Lyon, France.
Marie KaranianDepartment of Medical Oncology, Centre Leon Berard, Lyon, France.
Isabelle Ray-CoquardDepartment of Medical Oncology, Centre Leon Berard, Lyon, France.
Jean-Yves BlayDepartment of Medical Oncology, Centre Leon Berard, Lyon, France.
Centre Léon Bérard · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal (GI) tract. Most of them (>75%) are driven by an oncogenic initiating event involving activating mutations of the genes encoding for tyrosine kinase, KIT or platelet derived growth factor receptor alpha (PDGFRA). Efficacy of the tyrosine kinase Inhibitor imatinib is now well established for advanced disease. For localized GISTs, 3 years treatment is the recommended adjuvant therapy for high risk patients. Whether a longer duration and selection of patients for this adjuvant therapy in localized GISTs remains is not yet established (PERSIST-5 study). Similarly, it will be important to further refine the definition of the population of GIST patients at high risk of relapse including molecular criteria (

Indexed as

adjuvantGastrointestinal stromal tumor (GIST)imatinib

Identifiers

PMID31143845
PMCPMC6509420
OpenAlexW2936767216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.