Evidence map›Paper›PMID 31143783›Full record

ArticleJournal of immunology research2019

The Effects of Immunosuppressive Factors on Primary Dendritic Cells from C57BL/6 and CBA Mice.

Vasiliy V Kurilin, Julia N Khantakova, Valeriy P Tereschenko, Julia A Lopatnikova, Irina A Obleukhova, Sergey V Sennikov

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Unique Features of the Immune Response in BTBR Mice.International journal of molecular sciences · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vasiliy V KurilinLaboratory of Molecular Immunology, Federal State Budgetary Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya St. 14, Novosibirsk, 630099, Russia.ORCID 0000-0002-5617-0450
Julia N KhantakovaLaboratory of Molecular Immunology, Federal State Budgetary Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya St. 14, Novosibirsk, 630099, Russia.ORCID 0000-0001-9281-9002
Valeriy P TereschenkoLaboratory of Molecular Immunology, Federal State Budgetary Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya St. 14, Novosibirsk, 630099, Russia.ORCID 0000-0002-1620-6447
Julia A LopatnikovaLaboratory of Molecular Immunology, Federal State Budgetary Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya St. 14, Novosibirsk, 630099, Russia.ORCID 0000-0003-0089-5054
Irina A ObleukhovaLaboratory of Molecular Immunology, Federal State Budgetary Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya St. 14, Novosibirsk, 630099, Russia.ORCID 0000-0003-2180-3243
Sergey V SennikovLaboratory of Molecular Immunology, Federal State Budgetary Institution "Research Institute of Fundamental and Clinical Immunology", Yadrintsevskaya St. 14, Novosibirsk, 630099, Russia.ORCID 0000-0002-7366-7768
Research Institute of Fundamental and Clinical Immunology · RUNovosibirsk State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDendritic cells (DCs) control immune responses by modulating T and B cells towards effector or tolerogenic responses. In this study, we evaluated the effects of different immunosuppressive molecules on the phenotypic and functional characteristics of primary dendritic cells from C57BL/6 and CBA mice.

methodsDCs were derived from bone marrow cells in the presence of rmGM-CSF and rmIL-4. DCs were then treated with different types of immunosuppressive molecules (rmIL-10, rmTGF-

resultsTolerogenic factors were found to have different effects on DCs C57Bl/6 mice. In C57Bl/6 mice, BAY 11-7082 alone had no effect on the expression of DC maturation molecules (CD80, CD86). Transforming growth factor beta (TGF-

conclusionThese results indicate that TGF-

Indexed as

AnimalsCell DifferentiationCells, CulturedCoculture TechniquesDendritic CellsDrug SynergismDrug Therapy, CombinationImmunosuppressive AgentsInterleukin-10Lymphocyte ActivationMiceMice, Inbred C57BLMice, Inbred CBANF-kappa BNitrilesPrimary Cell Culture3-(4-methylphenylsulfonyl)-2-propenenitrileImmunosuppressive AgentsInterleukin-10NF-kappa BNitrilesSulfonesTransforming Growth Factor beta

Identifiers

PMID31143783
PMCPMC6501430
OpenAlexW2939419394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.