Evidence map›Paper›PMID 31143780›Full record

ReviewJournal of immunology research2019

Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation.

Wenjie Zeng, Jie Shen, Tao Bo, Liangxin Peng, Hongbo Xu, Moussa Ide Nasser, Quan Zhuang, Mingyi Zhao

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Altered molecular signature of the intestinal microbiota in irritable bowel syndrome patients versus healthy controls: An updated systematic review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. The Consumption ofMicroorganisms · 2024
    Article
  17. Review
  18. Acupuncture influences multiple diseases by regulating gut microbiota.Frontiers in cellular and infection microbiology · 2024
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenjie ZengTransplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.ORCID 0000-0001-7384-8780
Jie ShenPediatric Department of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.ORCID 0000-0001-8823-6488
Tao BoPediatric Department of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Liangxin PengTransplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.ORCID 0000-0003-1878-5216
Hongbo XuDepartment of Surgery of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.ORCID 0000-0001-7684-4179
Moussa Ide NasserGuangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China.
Quan ZhuangTransplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.ORCID 0000-0001-5225-9282
Mingyi ZhaoPediatric Department of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.ORCID 0000-0002-2884-0736
Central South University · CNGuangdong General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient's intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). The aim of this review was followed through the recent literature survey on immunomodulatory effects and mechanisms of probiotics and FMT and also efficacy and safety of probiotics and FMT in clinical trials and applications.

Indexed as

Fecal Microbiota TransplantationProbioticsAnimalsClinical Trials as TopicFecesGastrointestinal MicrobiomeHost-Pathogen InteractionsHumansImmunomodulationInflammatory Bowel Diseases

Identifiers

PMID31143780
PMCPMC6501133
OpenAlexW2936397086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.