ArticleAvicenna journal of phytomedicine
Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
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- Niosome as a promising tool for increasing the effectiveness of anti-inflammatory compounds.EXCLI journal · 2024Review
- Modulators of diabetic neuropathy and inflammation fromJournal of traditional and complementary medicine · 2023Article
- Antiulcerogenic Potential of the Ethanolic Extract ofInternational journal of molecular sciences · 2022Article
- Transdermal Delivery of Capsaicin Nanoemulgel: Optimization, Skin Permeation andAdvanced pharmaceutical bulletin · 2022Article
- Important Flavonoids and Their Role as a Therapeutic Agent.Molecules (Basel, Switzerland) · 2020Review
- Polyphenols and Other Bioactive Compounds ofMolecules (Basel, Switzerland) · 2020Review
- Niosomes of activeChinese medicine · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMATERIALS AND
methodsBio-guided fractionation and isolation-schemes were used utilizing RP-HPLC, CC,
resultsThe outcomes showed that the most active fraction (FKCA) of AS was identified. Two of the three components of FKCA were identified by chromatographic-methods, while the third compound was isolated, its structure was elucidated and its was named Kromeic acid (KRA); FKCA contained Ferulic acid (27.5%), kromeic acid (48.1%), and chlorogenic acid (24.4%). AS, FKCA and KRA showed significant (p˂0.05) anti-inflammatory and antinociceptive potentials in the management of allodynia and thermal-hyperalgesia in NP. AS and FCKA showed comparatively equipotent antinociceptive-effects. FKCA showed higher antinociceptive effects than KRA suggesting additive-effects among FKCA components. The anti-inflammatory, insulin secretagogue, oxidative-stress reducing, and protective effects against NO-induced neuronal-toxicity might be amongst the possible mechanisms of tested compounds to alleviate NP.
conclusionHere, we report the isolation and structure elucidation of a novel quinic-acid derivative, KRA.
Indexed as
Identifiers
31143690PMC6526038W2912605213What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.