Evidence map›Paper›PMID 31143668›Full record

ArticleTranslational andrology and urology2019

Impact of advanced paternal age on the intracytoplasmic sperm injection (ICSI) outcomes in donor egg cycles.

Gianmartin Cito, Maria Elisabetta Coccia, Rita Picone, Andrea Cocci, Giorgio Ivan Russo, Giulio Garaffa, Rossella Fucci, Francesco Bertocci, Elena Borrani, Valentina Basile and 5 more

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In one paragraph

Article in Translational andrology and urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Advanced Paternal Age and Future Generations.Frontiers in endocrinology · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gianmartin CitoDepartment of Urologye, Careggi Hospital, University of Florence, Florence, Italy.
Maria Elisabetta CocciaAssisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
Rita PiconeAssisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
Andrea CocciDepartment of Urologye, Careggi Hospital, University of Florence, Florence, Italy.
Giorgio Ivan RussoDepartment of Urology, Vittorio Emanuele II, University of Catania, Catania, Italy.
Giulio GaraffaInstitute of Urology, University College London Hospitals, London, UK.
Rossella FucciAssisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
Francesco BertocciAssisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
Elena BorraniAssisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
Valentina BasileAssisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
Elisabetta MicelliDepartment of Obstetrics and Gynecology, Santa Chiara Hospital, University of Pisa, Pisa, Italy.
Luciana CriscuoliAssisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy.
Sergio SerniDepartment of Urologye, Careggi Hospital, University of Florence, Florence, Italy.
Marco CariniDepartment of Urologye, Careggi Hospital, University of Florence, Florence, Italy.
Alessandro NataliDepartment of Urologye, Careggi Hospital, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study is to assess the impact of paternal age on the oocyte-donation outcomes in intracytoplasmic sperm injection (ICSI) cycles.

methodsTwo hundred and seventy-eight infertile couples were retrospectively involved. Inclusion criteria were: infertility from almost 1 year, normal or sub-fertile seminal parameters, overall oocyte survival rate greater than 85%. Baseline characteristics included male age, recipient age, male body mass index (BMI), smoking, drinking status. Main outcome measures: fertilization rate (FR), cleavage rate (CR), pregnancy rate (PR).

resultsPatients were categorized in group 1 ≤45, group 2 >45 years. A total of 1,724 frozen oocytes were included. After warming, 1,642 oocytes survived. Median overall oocyte survival rate was 100% [interquartile range (IQR), 85-100%]. Median male age was 44±5.60 years (IQR, 31-70 years). Median recipients age was 42±3.62 years (IQR, 29-50 years). Group 1 included 166 men, group 2 112 men. Two hundred and seventy-eight fresh ICSI cycle were performed. "Two-pronuclear" (2PN) FR was 72.6%±0.20%, CR 93.0%±0.16%, PR 39.6%. Miscarriage rate was 25.5%. Live birth rate per cycles was 29.5%. Comparison between group 1, group 2 and ICSI outcomes confirmed an association with FR, resulting 80.0% (IQR, 67.0-83.0%) and 67.0% (IQR, 50.0-80.0%), respectively (P<0.01). There were no significant differences between the two groups with respect to seminal parameters.

conclusionsIt would be recommended more emphasis on the advancing male age when counselling older couples who undergo egg donation program.

Indexed as

Aging maleinfertilityintracytoplasmic sperm injection (ICSI)

Identifiers

PMID31143668
PMCPMC6511697

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.