Evidence map›Paper›PMID 31143497›Full record

ArticleBiomedical optics express2019

Multimodal endoscopy for colorectal cancer detection by optical coherence tomography and near-infrared fluorescence imaging.

Yan Li, Zhikai Zhu, Jason J Chen, Joseph C Jing, Chung-Ho Sun, Sehwan Kim, Phil-Sang Chung, Zhongping Chen

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

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  20. 5G Use in Healthcare: The Future is Present.JSLS : Journal of the Society of Laparoendoscopic Surgeons
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yan LiBeckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA.
Zhikai ZhuBeckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA.
Jason J ChenBeckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA.
Joseph C JingBeckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA.
Chung-Ho SunBeckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA.
Sehwan KimDepartment of Biomedical Engineering, College of Medicine, Dankook University, Cheonan 31116, South Korea.
Phil-Sang ChungDepartment of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, South Korea.
Zhongping ChenBeckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA.
University of California, Irvine · USDankook University · KR

Funding

Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
NEI NIH HHS R01 EY026091NEI NIH HHS R01 EY028662NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01 HL127271
6 · The paper itself

Abstract

While colonoscopy is the gold standard for diagnosis and classification of colorectal cancer (CRC), its sensitivity and specificity are operator-dependent and are especially poor for small and flat lesions. Contemporary imaging modalities, such as optical coherence tomography (OCT) and near-infrared (NIR) fluorescence, have been investigated to visualize microvasculature and morphological changes for detecting early stage CRC in the gastrointestinal (GI) tract. In our study, we developed a multimodal endoscopic system with simultaneous co-registered OCT and NIR fluorescence imaging. By introducing a contrast agent into the vascular network, NIR fluorescence is able to highlight the cancer-suspected area based on significant change of tumor vascular density and morphology caused by angiogenesis. With the addition of co-registered OCT images to reveal subsurface tissue layer architecture, the suspected regions can be further investigated by the altered light scattering resulting from the morphological abnormality. Using this multimodal imaging system, an

Identifiers

PMID31143497
PMCPMC6524571
OpenAlexW2939566823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.