Evidence map›Paper›PMID 31143295›Full record

ArticleAsian journal of neurosurgery

Bone Morphogenetic Protein in the Repair of Cerebrospinal Fluid Leak after Transsphenoidal Surgery.

Dejan Slavnic, Richard Floyd Cook, Matthew Bahoura, Gijong Paik, Doris Wl Tong, Clifford M Houseman, Ryan J Barrett, Teck-Mun Soo

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PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of neurosurgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dejan SlavnicDepartment of Surgery, Providence-Providence Park Hospitals, College of Human Medicine, Michigan State University, East Lansing, Southfield, Michigan, USA.
Richard Floyd CookDepartment of Surgery, Providence-Providence Park Hospitals, College of Human Medicine, Michigan State University, East Lansing, Southfield, Michigan, USA.
Matthew BahouraMichigan Spine and Brain Surgeons, Providence-Providence Park Hospitals, Southfield, Michigan, USA.
Gijong PaikMichigan Spine and Brain Surgeons, Providence-Providence Park Hospitals, Southfield, Michigan, USA.
Doris Wl TongDepartment of Surgery, Providence-Providence Park Hospitals, College of Human Medicine, Michigan State University, East Lansing, Southfield, Michigan, USA.
Clifford M HousemanDepartment of Surgery, Providence-Providence Park Hospitals, College of Human Medicine, Michigan State University, East Lansing, Southfield, Michigan, USA.
Ryan J BarrettDepartment of Surgery, Providence-Providence Park Hospitals, College of Human Medicine, Michigan State University, East Lansing, Southfield, Michigan, USA.
Teck-Mun SooDepartment of Surgery, Providence-Providence Park Hospitals, College of Human Medicine, Michigan State University, East Lansing, Southfield, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrent cerebrospinal fluid (CSF) leak carries significant morbidity. We sought to demonstrate that bone morphogenetic protein (BMP) use is effective and safe for the repair of recurrent CSF leak after a transsphenoidal pituitary tumor resection (TSPTR). MATERIALS AND

methodsWe reviewed charts and radiographic data of consecutive patients who underwent BMP repair of recurrent CSF leak after TSPTR from January 2010 to June 2015 and who failed previous multilayer closure. We detailed the technique for constructing and placing a BMP-DuraGen patch for the repair. The primary variables include postoperative computed tomography/magnetic resonance imaging (CT/MRI) evidence of ectopic bone growth or inflammation, newly diagnosed systemic neoplasm within 1 year, and recurrent CSF leak. Secondary outcome is the length of stay after BMP repair. All patients were followed up radiographically and through phone interview.

resultsFour patients underwent BMP repair of recurrent CSF leak after TSPTR. The average postoperative CT/MRI interval was 22 months. Postoperative CT/MRI revealed no ectopic bone formation or inflammatory changes around the site of BMP application. There was no recurrence of CSF leak or newly diagnosed neoplasm from both chart review and phone interview.

conclusionsWe demonstrate that the use of BMP is a safe and an effective treatment in the repair of recurrent CSF leaks after TSPTR.

Indexed as

Bone morphogenetic proteinpituitaryrecurrent cerebrospinal fluid leaktranssphenoidal

Identifiers

PMID31143295
PMCPMC6515993

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.