ArticleAsian journal of neurosurgery
Solving the Riddle of "Idiopathic" in Idiopathic Intracranial Hypertension and Normal Pressure Hydrocephalus: An Imaging Study of the Possible Mechanisms - Monro-Kellie 3.0.
Article in Asian journal of neurosurgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Oculomotor Synkinesis Secondary to Meningocele: Report of a Rare Case.The Indian journal of radiology & imaging · 2026Article
- Monro-Kellie 4.0: moving from intracranial pressure to intracranial dynamics.Critical care (London, England) · 2025Review
- Diffusion-Weighted Imaging Reveals Impaired Glymphatic Clearance in Idiopathic Intracranial Hypertension.AJNR. American journal of neuroradiology · 2024Article
- The ligamentous cervical instability etiology of human disease from the forward head-facedown lifestyle: emphasis on obstruction of fluid flow into and out of the brain.Frontiers in neurology · 2024Article
- Idiopathic Intracranial Hypertension is Associated with a Higher Burden of Visible Cerebral Perivascular Spaces: The Glymphatic Connection.AJNR. American journal of neuroradiology · 2021Article
- Hydrocephalic Dementia: Revisited with Multimodality Imaging and toward a Unified Imaging Approach.Journal of neurosciences in rural practice · 2021Article
- Transcranial Doppler for Monitoring and Evaluation of Idiopathic Intracranial Hypertension.Journal of neurosciences in rural practice · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic intracranial hypertension (IIH) and normal pressure hydrocephalus (NPH) represent a cluster of typical clinical and imaging findings, with no evident etiological cause noted. In this study, we have proposed a model for IIH and NPH called Monroe-Kellie 3.0 (MK 3.0). IIH and NPH may be entities which represent opposite sides of the same coin with venous system and cerebrospinal fluid (CSF) as core drivers for both these entities. MATERIALS AND
methodsIIH and NPH volume data were collected, voxel-based morphometry analysis was performed without normalization, and the distribution of the individual volumes of gray matter, white matter, and CSF was statistically analyzed. Visual morphometry analyses of segmented data were performed, and the findings in routine magnetic resonance imaging (MRI) were noted to build a model for IIH and NPH.
resultsIn IIH and NPH when the volumes were compared with controls, the distribution was similar. Furthermore, the morphometric changes noted in the MRI and segmented volume data were analyzed and the results were suggestive of changes in elastic property of brain causing a remodeling of brain shape and resulting in minor brain shift in the skull vault, and the resulting passive displacement of CSF which has been termed as MK 3.0.
conclusionThis model helps to put the clinical and imaging findings and complications of treatment in single perspective.
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