Evidence map›Paper›PMID 31143187›Full record

ArticleFrontiers in immunology2019

Discriminatory Molecular Biomarkers of Allergic and Nonallergic Asthma and Its Severity.

Selene Baos, David Calzada, Lucía Cremades-Jimeno, MªÁngeles de Pedro, Joaquín Sastre, César Picado, Joaquín Quiralte, Fernando Florido, Carlos Lahoz, Blanca Cárdaba

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06163807 (Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06163807 recruitingnot on this mapstarted 2025, after this paper: background citation

Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry

Typeobservational_patient_registrySponsorInstituto de Investigación Sanitaria de la Fundación Jiménez DíazRan2025 to 2026Enrolled1,200ConditionsChronic AsthmaArmsAntiasthmatic
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Evaluating the Influence ofBiomolecules · 2025
    Article
  4. Article
  5. Article
  6. The Role ofInternational journal of molecular sciences · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Selene BaosImmunology Department, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.
David CalzadaImmunology Department, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.
Lucía Cremades-JimenoImmunology Department, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.
MªÁngeles de PedroImmunology Department, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.
Joaquín SastreCIBERES, CIBER of Respiratory Diseases, Madrid, Spain.
César PicadoCIBERES, CIBER of Respiratory Diseases, Madrid, Spain.
Joaquín QuiralteAllergy Department, Vírgen del Rocío University Hospital, Seville, Spain.
Fernando FloridoAllergy Department, San Cecilio University Hospital, Granada, Spain.
Carlos LahozImmunology Department, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.
Blanca CárdabaImmunology Department, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.
Centro de Investigación en Red en Enfermedades Cardiovasculares · ESHospital Universitario Fundación Jiménez Díaz · ESUniversidad Autónoma de Madrid · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Universitario Virgen del Rocío · ESInstituto de Investigación Biosanitaria de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma is a complex disease comprising various phenotypes and endotypes, all of which still need solid biomarkers for accurate classification. In a previous study, we defined specific genes related to asthma and respiratory allergy by studying the expression of 94 genes in a population composed of 4 groups of subjects: healthy control, nonallergic asthmatic, asthmatic allergic, and nonasthmatic allergic patients. An analysis of differential gene expression between controls and patients revealed a set of statistically relevant genes mainly associated with disease severity, i.e.,

Indexed as

AdultAgedAsthmaBiomarkersChitinase-3-Like Protein 1Diagnosis, DifferentialDisease ProgressionFemaleHumansHypersensitivityInterleukin-10Interleukin-8Leukocytes, MononuclearMaleMiddle AgedPhenotypeBiomarkersChitinase-3-Like Protein 1Interleukin-10Interleukin-8allergyasthmabiomarkersgene expressionprotein expression

Identifiers

PMID31143187
PMCPMC6521078
OpenAlexW2944643355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.