Evidence map›Paper›PMID 31143033›Full record

ArticleAnnals of pediatric cardiology

Acetaminophen in low doses for closure of the ductus arteriosus of the premature.

Adriana Furletti Machado Guimarães, Fátima Derlene Rocha Araújo, Zilda Maria Alves Meira, Henrique Assis Fonseca Tonelli, Guilherme Gomes Duarte, Lívia Castro Ribeiro, Gabriele Queiroz Monteiro Rezende, Sandra Regina Tolentino Castilho

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Increasing Alprostadil Requirements in a Neonate With Cardiac Anomalies and Co-administration of Rectal and Oral Acetaminophen.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
    Article
  3. Article
  4. Review
  5. Article
  6. Oral Versus Intravenous Medications for Treatment of Patent Ductus Arteriosus in Preterm Neonates: A Cost-Saving Initiative.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adriana Furletti Machado GuimarãesDepartment of Pediatrics, Division of Neonatology, Hospital Foundation of Minas Gerais State, Minas Gerais, Brazil.
Fátima Derlene Rocha AraújoDepartment of Pediatrics, Division of Pediatric Cardiology, Clinics Hospital of the Federal University of Minas Gerais, Minas Gerais, Brazil.
Zilda Maria Alves MeiraDepartment of Pediatrics, Division of Pediatric Cardiology, Clinics Hospital of the Federal University of Minas Gerais, Minas Gerais, Brazil.
Henrique Assis Fonseca TonelliDepartment of Pediatrics, Division of Pediatric Cardiology, Clinics Hospital of the Federal University of Minas Gerais, Minas Gerais, Brazil.
Guilherme Gomes DuarteDepartment of Pediatrics, Division of Pediatric Cardiology, Clinics Hospital of the Federal University of Minas Gerais, Minas Gerais, Brazil.
Lívia Castro RibeiroDepartment of Pediatrics, Division of Pediatric Cardiology, Clinics Hospital of the Federal University of Minas Gerais, Minas Gerais, Brazil.
Gabriele Queiroz Monteiro RezendeDepartment of Pediatrics, Division of Neonatology, Hospital Foundation of Minas Gerais State, Minas Gerais, Brazil.
Sandra Regina Tolentino CastilhoDepartment of Pediatrics, Division of Pediatric Cardiology, Clinics Hospital of the Federal University of Minas Gerais, Minas Gerais, Brazil.
Universidade Federal de Minas Gerais · BRFundação Hospitalar do Estado de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of the study is to report the experience with acetaminophen in low doses as an alternative to the treatment of the ductus arteriosus of the preterm newborn. MATERIALS AND

methodsRetrospective study including preterm newborns with patent ductus arteriosus who received oral acetaminophen because treatment with indomethacin had failed or is contraindicated. A dosage consisted of a first dose of 25 mg/kg and maintenance doses of 30 mg/kg/day, for 3 to 7 days. A second cycle was administered in cases of reopening of the ductus arteriosus. The rates of ductal closure and surgery were calculated. Patients were categorized into responder and nonresponder groups for acetaminophen, and the average values of ductal diameter, weight, gestational age, and postnatal age were compared.

resultsEighty-seven preterm newborns, with a postnatal age from 3 to 27 days, with average values of ductus arteriosus equal to 2.5 ± 0.8 mm/kg, gestational age 27.2 ± 1.9 weeks, and birth weight 888.9 ± 241 g, received acetaminophen for 3 to 7 days. A second cycle was administered in 15 preterm newborns. The ductus closure rate, after one or two cycles, was 74.7%, and the recommendations for surgical closure were progressively reduced from 50% in the 1

conclusionsAcetaminophen in low doses showed to be an effective alternative for the closure of the ductus arteriosus for preterm newborns in whom treatment with indomethacin or ibuprofen failed or was contraindicated.

Indexed as

Acetaminophenductus arteriosusechocardiographyindomethacinpremature

Identifiers

PMID31143033
PMCPMC6521660
OpenAlexW2956412634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.