ReviewJournal of Indian Society of Periodontology
Most effective method for the management of physiologic gingival hyperpigmentation: A systematic review and meta-analysis.
Review in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Meta-analysis of randomized controlled trials: efficacy of vitamin C mesotherapy for gingival hyperpigmentation in adults.BMC oral health · 2025Pooled it
- Efficacy of different gingival graft de-epithelialization methods: A parallel-group randomized clinical trial.Clinical oral investigations · 2025Trial
- Injectable platelet rich fibrin effect on laser depigmented gingiva: a clinical randomized controlled split mouth trial with histological assessment.Journal of applied oral science : revista FOB · 2024Trial
- Vitamin C mesotherapy versus diode laser for the esthetic management of physiologic gingival hyperpigmentation: a randomized clinical trial.BMC oral health · 2023Trial
- Comparison of Er,Cr:YSGG laser and diode laser in the treatment of gingival melanin pigmentation: a randomized clinical trial.Lasers in medical science · 2023Trial
- Article
- How Effective Is Vitamin C for Gingival Depigmentation? A Scoping Review.Clinical and experimental dental research · 2026Article
- Article
- Concurrent infusion of glutathione, tranexamic acid, and Vitamin C as oral mesotherapeutic agents for management of gingival hyperpigmentation: A case series.Journal of conservative dentistry and endodontics · 2025Article
- Article
- Evaluation of pain during gingival depigmentation using diode laser and conventional scalpel technique.Bioinformation · 2025Article
- Evaluation of the degree of knowledge of gingival melanosis between professionals and students: observational and cross-sectional study.Frontiers in oral health · 2025Article
- Comparison of Various Minimally Invasive Techniques for the Management of Gingival Hyperpigmentation: A Case Report.Cureus · 2024Article
- Efficacy and Risks of Different Treatments for Oral Hyperpigmentation: A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2023Review
- A Comparative Histological Study of Gingival Depigmentation by 808 and 445 nm Diode Lasers.Journal of lasers in medical sciences · 2023Article
- Comparison of the Diode Laser Wavelengths 445 nm and 810 nm in Gingival Depigmentation - A Clinical Evaluation.Journal of lasers in medical sciences · 2023Article
- Article
- Gingival Melanin Depigmentation Using a Diode 808-nm Laser: A Case Series.Journal of lasers in medical sciences · 2022Article
- Efficacy of surgical stripping and diode laser-assisted gingival depigmentation techniques in terms of patient's perspective, clinical and histological evaluation: A randomized clinical study.Journal of Indian Society of PeriodontologyArticle
- Clinical and patient-reported outcomes of microneedling with ascorbic acid versus scalpel technique for gingival depigmentation: A randomized clinical trial.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimGingival hyperpigmentation is an esthetic problem. The aim of the present study was to identify most effective treatment modality for managing generalized physiological gingival pigmentation. MATERIALS AND
methodsA systematic review and meta-analysis were done (1919 to October 2018) using PubMed, CINHAL, Dental and Oral Science, and manual searches. Twenty-five articles were finally reviewed. Only human clinical trials were considered with physiological gingival pigmentation treated with different depigmentation methods and compared with surgical stripping. The outcome was the achievement of gingival depigmentation and its recurrence. RevMan software was used for data analysis.
resultsOf 26,132 articles, 25 met the inclusion criteria. Seventeen were randomized control trials and 8 were nonrandomized control trials. Most of the studies were on laser. The control group was scalpel surgery. Majority of studies showed no difference in compared treatment modality. A meta-analysis compared laser ablation with surgical stripping revealed a nonsignificance difference regarding recurrence (
conclusionsSurgical stripping has been the conventional treatment of choice, but our review showed that new techniques are equally effective or even better. Laser especially diode laser was the most frequently used technique and showed better esthetic outcomes, less pain, faster healing, and patients' preference and satisfaction after treatment. However, laser showed more regimentation at 6-month evaluation. More good quality randomized controlled trials with different depigmentation methods are needed to draw strong conclusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.