ArticleNature medicine2019
Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.
Open access · greenAbstract read
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 1 pooled it
24.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
201 citing papers in PubMed, 1 synthesis or guideline pooled it, 314 citations in OpenAlex.
- The Association Between Vaginal Microbiota Dysbiosis, Bacterial Vaginosis, and Aerobic Vaginitis, and Adverse Pregnancy Outcomes of Women Living in Sub-Saharan Africa: A Systematic Review.Frontiers in public health · 2020Pooled it
- Trial
- Probiotic treatment with specific lactobacilli does not improve an unfavorable vaginal microbiota prior to fertility treatment-A randomized, double-blinded, placebo-controlled trial.Frontiers in endocrinology · 2022Trial
- Trial
- Parental microbiome programming of early-life neurodevelopment: multi-niche contributions through the microbiome-gut-brain axis.Gut microbes · 2026Review
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Association between dental flossing frequency and oral microbiome in U.S. adults.Annals of medicine · 2026Article
- Vaginal Ecosystem During Gestation and Puerperium: Microbiota, Dysbiosis, Infection and Fetal-Maternal Implications.Microorganisms · 2026Review
- The Impact of the Vaginal Microbiome and Microbial Metabolites on HIV Transmission at the Female Reproductive Tract Epithelial Barrier.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Study of microbe-microbe interactions between the sexually transmitted parasitebioRxiv : the preprint server for biology · 2026Article
- Vaginal microbiomes and their pertinent social context: a microbial ecological review proffering AMR-STI acquisition and emergence.Biology of sex differences · 2026Review
- Vaginal microbiome composition in pregnant and non-pregnant women: community structure, population variation, clinical impact, and metagenomics approaches.Infection and immunity · 2026Review
- Genomic landscape of the human vaginal microbiome is linked to host genetics and population of origin.Nature genetics · 2026Article
- The Maternal Microbiome in Pregnancy: From Physiological Changes to Dysbiosis and Obstetrical Complications-Therapeutic Perspectives.Life (Basel, Switzerland) · 2026Review
- Lactobacillus iners at the nexus of microbiota, immunity, and pregnancy.Journal of reproductive immunology · 2026Review
- Differential Host Gene Expression Associated with Non-Research square · 2026Article
- The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Vaginal microbiota composition in pregnant women following cervical conization and radical trachelectomy.Scientific reports · 2026Article
- Association of vaginal microbiome, cytokines, and spontaneous preterm birth among Chinese women: a nested case-control study.Microbiology spectrum · 2026Article
- The vaginal microbiome in pregnancy and preterm birth: mechanisms, disparities, and therapeutic opportunities.NPJ biofilms and microbiomes · 2026Review
141 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
41 authors at 3 institutions in 1 country.
Myrna G Serrano *Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Hardik I Parikh *Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
J Paul BrooksCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
David J EdwardsCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Tom J ArodzCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Laahirie EdupugantiDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Bernice HuangDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Philippe H GirerdCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Yahya A BokhariDepartment of Computer Science, College of Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Steven P BradleyDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Jamie L BrooksDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Molly R DickinsonDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Jennifer I DrakeDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Robert A DuckworthDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Stephen S FongCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Abigail L GlascockVCU Life Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Sophonie JeanDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Nicole R JimenezDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Joseph KhouryDivision of General Pediatrics, Department of Pediatrics, School of Medicine, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, USA.
Vishal N KopardeDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Ana M LaraDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Vladimir LeeDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Andrey V MatveyevDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Sarah H MiltonDepartment of Obstetrics and Gynecology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Shreni D MistryDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Sarah K RozyckiDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Nihar U ShethVCU Life Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Ekaterina SmirnovaDepartment of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-9577-4102
Stephany C VivadelliDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
N Romesh WijesooriyaDivision of General Pediatrics, Department of Pediatrics, School of Medicine, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, USA.
Jie XuCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Ping XuDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Donald O ChaffinGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
Amber L SextonGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
Michael G GravettGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
Craig E RubensGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
Karen D Hendricks-MuñozCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Kimberly K JeffersonDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Jerome F StraussCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Jennifer M FettweisDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-5466-3000
Gregory A BuckDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA. gregory.buck@vcuhealth.org.ORCID http://orcid.org/0000-0003-4621-3987
Virginia Commonwealth University · USGlobal Alliance to Prevent Prematurity and Stillbirth · USUniversity of Washington · US
Funding
A Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54HD080784 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2014 to 2015
$8.2MThe Vaginal Microbiome: Disease, Genetics and the EnvironmentUH3AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2010 to 2012
$6.8MVirginia Commonwealth University Initiative for Maximizing Student DevelopmentR25GM090084 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, LLOYD, JOYCE A. · 2010 to 2022
$5.2MThe Influence of HPV on Preterm Birth via Immunomodulation of the MicrobiomeR01HD092415 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2017 to 2021
$3.6MA Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54DE023786 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2013 to 2014
$3.0MThe Vaginal Microbiome: Disease, Genetics and the EnvironmentUH2AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, CORNELISSEN, CYNTHIA N · 2009 to 2009
$1.0MTransmission of Maternal Vaginal and Gut Microbiome and Obesity Risk in OffspringR21HD092965 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI FETTWEIS, JENNIFER MAUREEN, WICKHAM, EDMOND PRYCE · 2017 to 2018
$416kNIAID NIH HHS UH2 AI083263NIAID NIH HHS UH3 AI083263NICHD NIH HHS R01 HD092415NICHD NIH HHS R21 HD092965NICHD NIH HHS U54 HD080784NIDCR NIH HHS U54 DE023786NIGMS NIH HHS R25 GM090084
Abstract
The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.
Indexed as
MicrobiotaAdultBiodiversityBlack or African AmericanCohort StudiesCross-Sectional StudiesFemaleHispanic or LatinoHost Microbial InteractionsHumansPregnancySocial ClassVaginaWhite People
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