ArticleNature medicine2019
The vaginal microbiome and preterm birth.
Open access · hybridAbstract read
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 600 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
600citing papers in PubMed, 2 pooled it
80.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
600 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,005 citations in OpenAlex.
- Association Between Vaginal Microbiota and Cervical Dysplasia Due to Persistent Human Papillomavirus Infection: A Systematic Review of Evidence from Shotgun Metagenomic Sequencing Studies.International journal of molecular sciences · 2025Pooled it
- Vaginal metatranscriptome meta-analysis reveals functional BV subgroups and novel colonisation strategies.Microbiome · 2024Pooled it
- Trial
- Postbiotics originated from Lactobacillus crispatus NCU-31 improves vulvar lichen sclerosus: a randomized, double-blind controlled trial.BMC microbiology · 2026Trial
- Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial.NPJ biofilms and microbiomes · 2025Trial
- Effect of contraceptive methods on the vaginal microbiome and host immune factors.Contraception · 2025Trial
- Vaginal microbiota stability over 18 months in young student women in France.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Trial
- Review
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Vaginal formulations selectively target Lactobacillus iners and Candida spp. while preserving Lactobacillus crispatus.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- The Human Vaginal Virome: Composition, Microbiome Interactions, and Implications for Bacterial Vaginosis, HPV Persistence, and Preterm Birth.Microorganisms · 2026Review
- Gardnerella enrichment in the vaginal microbiome of women with gestational diabetes mellitus is associated with lower fetal birthweight percentiles.Diabetologia · 2026Observational
- Article
- Microbiome and chronic pelvic pain in women: a mini-review.Human reproduction (Oxford, England) · 2026Review
- The Impact of First-Trimester Vaginal Microecology on Spontaneous Abortion: A Retrospective Cohort Study.Pathogens (Basel, Switzerland) · 2026Article
- Gut Dysbiosis in Selected Gynecological Diseases Associated with Female Infertility: A Scoping Review.Journal of clinical medicine · 2026Review
- Differential Impact of Bacterial Infection on Preterm Birth in Singleton and Twin Pregnancies and Its Association with Cervical Cerclage or Arabin Pessary: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Alterations in Vaginal Microbiota Associated with Pregnancy Outcomes in Dairy Cows Revealed by 16S rRNA Gene Sequencing.Microorganisms · 2026Article
- Longitudinal changes in the vaginal microbiome associate with spontaneous preterm birth: a focus on stability and specific taxa in a Chinese cohort.Microbiology spectrum · 2026Article
- The Vaginal Microbiota of Adult Malagasy Women of Reproductive Age in the Marovoay District: First Characterization and Exploration of Associations With Human Papillomavirus and Schistosoma haematobium Infections.The Journal of infectious diseases · 2026Article
540 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
45 authors at 6 institutions in 1 country.
Jennifer M FettweisDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-5466-3000
Myrna G SerranoDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
J Paul BrooksCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
David J EdwardsCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Philippe H GirerdDepartment of Obstetrics and Gynecology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Hardik I ParikhDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Bernice HuangDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Tom J ArodzCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Laahirie EdupugantiDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Abigail L GlascockVCU Life Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Jie XuCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Nicole R JimenezDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Stephany C VivadelliDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Stephen S FongCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Nihar U ShethCenter for the Study of Biological Complexity, VCU Life Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Sophonie JeanDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Vladimir LeeDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Yahya A BokhariDepartment of Computer Science, College of Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Ana M LaraDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Shreni D MistryDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Robert A DuckworthDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Steven P BradleyDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Vishal N KopardeCenter for the Study of Biological Complexity, VCU Life Sciences, Virginia Commonwealth University, Richmond, VA, USA.
X Valentine OrendaDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0002-2168-5825
Sarah H MiltonDepartment of Obstetrics and Gynecology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Sarah K RozyckiSchool of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Andrey V MatveyevDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Michelle L WrightNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9348-8740
Snehalata V HuzurbazarDepartment of Biostatistics, School of Public Health, West Virginia University, Morgantown, WV, USA.
Eugenie M JacksonDepartment of Biostatistics, School of Public Health, West Virginia University, Morgantown, WV, USA.
Ekaterina SmirnovaDepartment of Mathematical Sciences, University of Montana, Missoula, MT, USA.ORCID http://orcid.org/0000-0001-9577-4102
Jonas KorlachPacific Biosciences, Menlo Park, CA, USA.
Yu-Chih TsaiPacific Biosciences, Menlo Park, CA, USA.ORCID http://orcid.org/0000-0002-2958-0278
Molly R DickinsonDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Jamie L BrooksDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Jennifer I DrakeDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Donald O ChaffinGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
Amber L SextonGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
Michael G GravettGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
Craig E RubensGlobal Alliance to Prevent Prematurity and Stillbirth, Seattle, WA, USA.
N Romesh WijesooriyaDepartment of Pediatrics, School of Medicine, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, USA.
Karen D Hendricks-MuñozCenter for Microbiome Engineering and Data Analysis, Virginia Commonwealth University, Richmond, VA, USA.
Kimberly K JeffersonDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Jerome F StraussDepartment of Obstetrics and Gynecology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Gregory A BuckDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA. gregory.buck@vcuhealth.org.ORCID http://orcid.org/0000-0003-4621-3987
Virginia Commonwealth University · USGlobal Alliance to Prevent Prematurity and Stillbirth · USPacific Biosciences (United States) · USWest Virginia University · USEmory University · USUniversity of Washington · US
Funding
A Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54HD080784 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2014 to 2015
$8.2MThe Vaginal Microbiome: Disease, Genetics and the EnvironmentUH3AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2010 to 2012
$6.8MVirginia Commonwealth University Initiative for Maximizing Student DevelopmentR25GM090084 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, LLOYD, JOYCE A. · 2010 to 2022
$5.2MVirginia Commonwealth University Postbaccalaureate Research Education ProgramR25GM089614 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Rebecca Kelley Martin · 2010 to 2026
$4.9MThe Influence of HPV on Preterm Birth via Immunomodulation of the MicrobiomeR01HD092415 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2017 to 2021
$3.6MA Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54DE023786 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2013 to 2014
$3.0MThe Vaginal Microbiome: Disease, Genetics and the EnvironmentUH2AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, CORNELISSEN, CYNTHIA N · 2009 to 2009
$1.0MTransmission of Maternal Vaginal and Gut Microbiome and Obesity Risk in OffspringR21HD092965 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI FETTWEIS, JENNIFER MAUREEN, WICKHAM, EDMOND PRYCE · 2017 to 2018
$416kNIAID NIH HHS UH2 AI083263NIAID NIH HHS UH3 AI083263NICHD NIH HHS R01 HD092415NICHD NIH HHS R21 HD092965NICHD NIH HHS U54 HD080784NIDCR NIH HHS U54 DE023786NIGMS NIH HHS R25 GM089614NIGMS NIH HHS R25 GM090084
Abstract
The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency of preterm birth among populations within countries, and women of African ancestry disproportionately bear the burden of risk in the United States. In the present study, we report a community resource that includes 'omics' data from approximately 12,000 samples as part of the integrative Human Microbiome Project. Longitudinal analyses of 16S ribosomal RNA, metagenomic, metatranscriptomic and cytokine profiles from 45 preterm and 90 term birth controls identified harbingers of preterm birth in this cohort of women predominantly of African ancestry. Women who delivered preterm exhibited significantly lower vaginal levels of Lactobacillus crispatus and higher levels of BVAB1, Sneathia amnii, TM7-H1, a group of Prevotella species and nine additional taxa. The first representative genomes of BVAB1 and TM7-H1 are described. Preterm-birth-associated taxa were correlated with proinflammatory cytokines in vaginal fluid. These findings highlight new opportunities for assessment of the risk of preterm birth.
Indexed as
MicrobiotaAdultBiodiversityBlack or African AmericanCohort StudiesCytokinesFemaleHost Microbial InteractionsHumansInfant, NewbornInflammation MediatorsLongitudinal StudiesMetagenomicsPremature BirthRisk FactorsUnited StatesCytokinesInflammation Mediators
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.