ArticleNature2019
Genome-wide cell-free DNA fragmentation in patients with cancer.
3 registry-linked trialsAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 849 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
849citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gastric Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Assessment of a Novel Blood Test in Early Detection of the Five Common Cancers Based on the Investigation of the Circulating Tumour DNA
Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Who cites it
849 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Blood-Based Circulating Tumor DNA Assays for Early Colorectal Cancer Detection: A Systematic Review of Performance in Asymptomatic Screening Populations.International journal of cancer · 2026Pooled it
- The Predictive Role of ctDNA and CTCs in Patients with Advanced Non-Small Cell Lung Cancer Receiving Immunotherapy: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Genome-wide variation in cell-free DNA end-motif entropy predicts immunotherapy response in head and neck cancer.The Journal of clinical investigation · 2026Trial
- Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial.The Lancet. Oncology · 2025Trial
- Continuous versus Standard Palbociclib Treatment and Molecular Profiling of Solid Tissues and Liquid Biopsies in the CCTG MA.38 Trial in Advanced Breast Cancer.Cancer research communications · 2025Trial
- Inferring tissue origin from cell-free DNA in metastatic cancer.Cancer metastasis reviews · 2026Review
- Diagnostic Performance of cfDNA-Based Liquid Biopsy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.Cancer science · 2026Review
- Decoding coupled epigenetic-fragmentomic signals in circulating cell-free DNA for interpretable cancer diagnosis.Genome medicine · 2026Article
- Pulmonary nodules: classification, biomarkers, signaling pathways, diseases, early diagnosis and management.Signal transduction and targeted therapy · 2026Review
- Double-base deletions and signatures associated with platinum adducts in metastatic cancer.Nucleic acids research · 2026Article
- Towards liquid biopsy-based analysis of antitumour immunity.Nature reviews. Clinical oncology · 2026Review
- Decoding cancer with artificial intelligence: Transforming research, diagnosis, and therapy with future insights.Translational oncology · 2026Review
- Plasma nucleosome profiling reports on tumor burden and molecular subtypes in small cell lung cancer.The Journal of clinical investigation · 2026Article
- Review
- Review
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- Cell-free DNA genomic and fragmentomic features for early outcome prediction in large B cell lymphoma.Cell reports. Medicine · 2026Article
- Development and validation of a serum peptidomic signature for early detection of asymptomatic ovarian cancer: A multi-center prospective study.Cell reports. Medicine · 2026Article
- Beyond the Needle: Is Liquid Biopsy the Future of Veterinary Medicine?International journal of molecular sciences · 2026Review
- Novel Strategies for the Management of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: A Review.Journal of gastrointestinal cancer · 2026Review
789 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
36 authors.
Stephen Cristiano *The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alessandro Leal *The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jillian Phallen *The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacob Fiksel *The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vilmos AdleffThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel C BruhmThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sarah Østrup JensenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Jamie E MedinaThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Carolyn HrubanThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James R WhiteThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Doreen N PalsgroveThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Noushin NiknafsThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Valsamo AnagnostouThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Patrick FordeThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jarushka NaidooThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kristen MarroneThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Julie BrahmerThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brian D WoodwardDivision of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
Hatim HusainDivision of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
Karlijn L van RooijenDepartment of Medical Oncology, University Medical Center, Utrecht University, Utrecht, The Netherlands.
Mai-Britt Worm ØrntoftDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Anders Husted MadsenDepartment of Surgery, Herning Regional Hospital, Herning, Denmark.
Cornelis J H van de VeldeDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Marcel VerheijDepartment of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Annemieke CatsDepartment of Gastrointestinal Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Cornelis J A PuntDepartment of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Geraldine R VinkDepartment of Medical Oncology, University Medical Center, Utrecht University, Utrecht, The Netherlands.
Nicole C T van GriekenDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Miriam KoopmanDepartment of Medical Oncology, University Medical Center, Utrecht University, Utrecht, The Netherlands.
Remond J A FijnemanDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Julia S JohansenDepartment of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Hans Jørgen NielsenDepartment of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.
Gerrit A MeijerDepartment of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Claus Lindbjerg AndersenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Robert B ScharpfThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. rscharpf@jhu.edu.
Victor E VelculescuThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. velculescu@jhmi.edu.
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6MEPIDEMIOLOGY AND BIOSTATISTICS OF AGINGT32AG000247 · NIA · JOHNS HOPKINS UNIVERSITY · PI Karen J. Bandeen-Roche · 1996 to 2026
$13.2MTraining Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7MPredoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6MTraining Program In Cellular and Molecular MedicineT32GM135457 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAJINI RAO · 2020 to 2026
$5.4MLarge-Scale Genetic Analyses of Human CancerR01CA121113 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANAGNOSTOU, VALSAMO, VELCULESCU, VICTOR E. · 2006 to 2022
$4.3MECOG-ACRIN Thoracic Malignancies Integrated Translational Science CenterU10CA180950 · NCI · EMORY UNIVERSITY · PI RAMALINGAM, SURESH S · 2014 to 2018
$2.9MOpportunities for Pathology Trainees in Cancer ResearchT32CA193145 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANDERS, ROBERT A., EBERHART, CHARLES G · 2015 to 2025
$2.6MNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA121113NCI NIH HHS T32 CA193145NCI NIH HHS U10 CA180950NIA NIH HHS T32 AG000247NIGMS NIH HHS T32 GM007814NIGMS NIH HHS T32 GM008752NIGMS NIH HHS T32 GM135457
Abstract
Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer
Indexed as
DNA FragmentationCase-Control StudiesCirculating Tumor DNACohort StudiesDNA Mutational AnalysisGenome, HumanHumansMachine LearningMutationNeoplasmsCirculating Tumor DNA
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.