Evidence map›Paper›PMID 31142835›Full record

ArticleNature2019

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus.

Serban L Ilca, Xiaoyu Sun, Kamel El Omari, Abhay Kotecha, Felix de Haas, Frank DiMaio, Jonathan M Grimes, David I Stuart, Minna M Poranen, Juha T Huiskonen

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. The assembly rules guiding hetero-oligomeric bacterioferritin organization and their evolutionary signature.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. DNA synthesis inside the hepatitis B virus creates a high-energy spool.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Nucleic Acid Packaging in Viruses.Sub-cellular biochemistry · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Serban L IlcaDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Xiaoyu SunMolecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Kamel El OmariDiamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot, UK.
Abhay KotechaDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Felix de HaasThermo Fisher Scientific, Eindhoven, The Netherlands.
Frank DiMaioDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.
Jonathan M GrimesDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
David I StuartDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Minna M PoranenMolecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Juha T HuiskonenDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. juha@strubi.ox.ac.uk.
Centre for Human Genetics · GBUniversity of Helsinki · FIDiamond Light Source · GBThermo Fisher Scientific (Netherlands) · NLUniversity of Oxford · GBUniversity of Washington · US

Funding

European Research CouncilMedical Research Council G1100525Medical Research Council MR/N00065X/1Wellcome Trust 109135/Z/15/AWellcome Trust 203141/Z/16/Z
6 · The paper itself

Abstract

Characterizing the genome of mature virions is pivotal to understanding the highly dynamic processes of virus assembly and infection. Owing to the different cellular fates of DNA and RNA, the life cycles of double-stranded (ds)DNA and dsRNA viruses are dissimilar. In terms of nucleic acid packing, dsDNA viruses, which lack genome segmentation and intra-capsid transcriptional machinery, predominantly display single-spooled genome organizations

Indexed as

Cryoelectron MicroscopyDNA PackagingLiquid CrystalsNucleic Acid ConformationBacteriophage phi 6Genome, ViralModels, MolecularRNA-Dependent RNA PolymeraseRNA, Double-StrandedRNA, ViralRNA-Dependent RNA PolymeraseRNA, Double-StrandedRNA, Viral

Identifiers

PMID31142835
OpenAlexW2947988065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.