Evidence map›Paper›PMID 31142834›Full record

ArticleNature2019

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage.

Alexander J Meeske, Sandra Nakandakari-Higa, Luciano A Marraffini

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 320 citations in OpenAlex.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexander J MeeskeLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA. ameeske@rockefeller.edu.
Sandra Nakandakari-HigaLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA.
Luciano A MarraffiniLaboratory of Bacteriology, The Rockefeller University, New York, NY, USA. marraffini@rockefeller.edu.
Rockefeller University · US

Funding

Generation of immunological memory by CRISPR-Cas systemsDP1GM128184 · NIGMS · ROCKEFELLER UNIVERSITY · PI MARRAFFINI, LUCIANO A · 2017 to 2021
$5.9M
Howard Hughes Medical InstituteNIGMS NIH HHS DP1 GM128184
6 · The paper itself

Abstract

Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci in prokaryotes are composed of 30-40-base-pair repeats separated by equally short sequences of plasmid and bacteriophage origin known as spacers

Indexed as

BacteriophagesCRISPR-Associated ProteinsCRISPR-Cas SystemsDNA VirusesEndodeoxyribonucleasesListeriaRNA, BacterialRNA, ViralCRISPR-Associated ProteinsEndodeoxyribonucleasesRNA, BacterialRNA, Viral

Identifiers

PMID31142834
PMCPMC6570424
OpenAlexW2946892453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.