Evidence map›Paper›PMID 31142802›Full record

ArticleScientific reports2019

Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization.

Chetan P Hans, Neekun Sharma, Sidharth Sen, Shuai Zeng, Rishabh Dev, Yuexu Jiang, Advitiya Mahajan, Trupti Joshi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  5. Molecules (Basel, Switzerland) · 2023
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  14. Long noncoding RNA: a dazzling dancer in tumor immune microenvironment.Journal of experimental & clinical cancer research : CR · 2020
    Review
  15. Toxicity of TiOInternational journal of molecular sciences · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chetan P HansDepartment of Cardiovascular Medicine, University of Missouri, Columbia, USA. HansCP@health.missouri.edu.ORCID http://orcid.org/0000-0003-1830-9084
Neekun SharmaDepartment of Cardiovascular Medicine, University of Missouri, Columbia, USA.
Sidharth SenMU Informatics Institute, University of Missouri, Columbia, USA.ORCID http://orcid.org/0000-0002-9196-204X
Shuai ZengDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, USA.
Rishabh DevDepartment of Cardiovascular Medicine, University of Missouri, Columbia, USA.
Yuexu JiangDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, USA.
Advitiya MahajanDepartment of Cardiovascular Medicine, University of Missouri, Columbia, USA.
Trupti JoshiMU Informatics Institute, University of Missouri, Columbia, USA.
University of Missouri · USUniversity of Missouri Health System · US

Funding

Role of Notch1 Signaling in Abdominal Aortic AneurysmR01HL124155 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANS, CHETAN · 2015 to 2019
$1.9M
NHLBI NIH HHS R01 HL124155
6 · The paper itself

Abstract

Naïve macrophages (Mφ) polarize in response to various environmental cues to a spectrum of cells that have distinct biological functions. The extreme ends of the spectrum are classified as M1 and M2 macrophages. Previously, we demonstrated that Notch1 deficiency promotes Tgf-β2 dependent M2-polarization in a mouse model of abdominal aortic aneurysm. The present studies aimed to characterize the unique set of genes regulated by Notch1 signaling in macrophage polarization. Bone marrow derived macrophages isolated from WT or Notch1

Indexed as

AnimalsAortic Aneurysm, AbdominalCell DifferentiationCell PolarityComputational BiologyDisease Models, AnimalFibromodulinGene Expression Regulation, DevelopmentalHumansInterferon-gammaInterleukin-13Interleukin-4LipopolysaccharidesMacrophage ActivationMacrophagesMiceFibromodulinFmod protein, mouseIFNG protein, mouseInterferon-gammaInterleukin-13Interleukin-4LipopolysaccharidesNotch1 protein, mouseReceptor, Notch1

Identifiers

PMID31142802
PMCPMC6541629
OpenAlexW2947001184

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.