ArticleScientific reports2019
A comparative genomics approach for identifying host-range determinants in Streptococcus thermophilus bacteriophages.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Diversity and prevalence of dairy streptococcal phages in two European dairy fermentation facilities over a one-year period.Microbial genomics · 2026Article
- Stable co-existence ofmBio · 2026Article
- The Zoetrope effect in phage evolution.Frontiers in microbiology · 2026Article
- Genomic landscape of completeFrontiers in microbiology · 2026Article
- The cell surface-associated rhamnose-glucose polysaccharide represents the receptor ofApplied and environmental microbiology · 2025Article
- Deep learning-guided structural analysis of a novel bacteriophage KPP105 against multidrug-resistantComputational and structural biotechnology journal · 2025Article
- Bacteriophage-host interactions in Streptococcus thermophilus and their impact on co-evolutionary processes.FEMS microbiology reviews · 2023Review
- Pan-metagenome reveals the abiotic stress resistome of cigar tobacco phyllosphere microbiome.Frontiers in plant science · 2023Article
- BipartiteApplied and environmental microbiology · 2022Article
- Dairy streptococcal cell wall and exopolysaccharide genome diversity.Microbial genomics · 2022Article
- Article
- Brussowvirus SW13 Requires a Cell Surface-Associated Polysaccharide To Recognize Its Streptococcus thermophilus Host.Applied and environmental microbiology · 2022Article
- Bacteriophage-host interactions as a platform to establish the role of phages in modulating the microbial composition of fermented foods.Microbiome research reports · 2022Review
- Interactions between the Prophage 919TP and ItsViruses · 2021Article
- Characterization and Genome Study of Novel Lytic Bacteriophages against Prevailing Saprophytic Bacterial Microflora of Minimally Processed Plant-Based Food Products.International journal of molecular sciences · 2021Article
- Biodiversity of Phages Infecting the Dairy BacteriumMicroorganisms · 2021Review
- Diverse Viruses Carrying Genes for Microbial Extremotolerance in the Atacama Desert Hyperarid Soil.mSystems · 2021Article
- Cell wall polysaccharides of Gram positive ovococcoid bacteria and their role as bacteriophage receptors.Computational and structural biotechnology journal · 2021Review
- Revisiting the host adhesion determinants of Streptococcus thermophilus siphophages.Microbial biotechnology · 2020Article
- Cell wall homeostasis in lactic acid bacteria: threats and defences.FEMS microbiology reviews · 2020Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative genomics has proven useful in exploring the biodiversity of phages and understanding phage-host interactions. This knowledge is particularly useful for phages infecting Streptococcus thermophilus, as they constitute a constant threat during dairy fermentations. Here, we explore the genetic diversity of S. thermophilus phages to identify genetic determinants with a signature for host specificity, which could be linked to the bacterial receptor genotype. A comparative genomic analysis was performed on 142 S. thermophilus phage genomes, 55 of which were sequenced in this study. Effectively, 94 phages were assigned to the group cos (DT1), 36 to the group pac (O1205), six to the group 5093, and six to the group 987. The core genome-based phylogeny of phages from the two dominating groups and their receptor binding protein (RBP) phylogeny corresponded to the phage host-range. A role of RBP in host recognition was confirmed by constructing a fluorescent derivative of the RBP of phage CHPC951, followed by studying the binding of the protein to the host strain. Furthermore, the RBP phylogeny of the cos group was found to correlate with the host genotype of the exocellular polysaccharide-encoding operon. These findings provide novel insights towards developing strategies to combat phage infections in dairies.
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