ArticleScientific reports2019
Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Genetic tools for studying cochlear inhibition.Frontiers in cellular neuroscience · 2024Review
- The role of epigenetic modifications in sensory hair cell development, survival, and regulation.Frontiers in cellular neuroscience · 2023Review
- Effects of Combined Gentamicin and Furosemide Treatment on Cochlear Macrophages.International journal of molecular sciences · 2022Article
- Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosisActa pharmaceutica Sinica. B · 2022Article
- A Stochastic Binary Model for the Regulation of Gene Expression to Investigate Responses to Gene Therapy.Cancers · 2022Article
- Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model.Frontiers in cellular neuroscience · 2022Article
- The DNA methylation inhibitor RG108 protects against noise-induced hearing loss.Cell biology and toxicology · 2021Article
- Experimental animal models of drug-induced sensorineural hearing loss: a narrative review.Annals of translational medicine · 2021Review
- Postnatal Changes of Neural Stem Cells in the Mammalian Auditory Cortex.International journal of molecular sciences · 2021Article
- Generation of a Spiral Ganglion Neuron Degeneration Mouse Model.Frontiers in cell and developmental biology · 2021Article
- Generation of Cochlear Hair Cells from Sox2 Positive Supporting Cells via DNA Demethylation.International journal of molecular sciences · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Regeneration of mature mammalian inner ear hair cells remains to be a challenge. This study aims to evaluate the ability of DNA methyltransferase (Dnmt) inhibitor 5-azacytidine (5-aza) to generate outer hair cells (OHCs) in a chemically-deafened adult mouse model. 5-aza was administrated into the mouse inner ear via the round window. Immunofluorescence was used to examine the expression of hair cell specific proteins following 5-aza treatment. The results showed that in the chemically-deafened mouse cochlea, new OHCs were found post 5-aza treatment, whereas OHCs were completely lost in saline-treated mice. New hair cells expressed multiple hair cell markers included Myosin VIIa, Pou4f3 and Myosin VI. Newly-generated hair cells presented in three cochlear turns and were able to survive for at least six weeks. The effects of new hair cells generation by 5-aza were concentration dependent. Quantitative PCR study indicates that 5-aza may function through Dnmt1 inhibition. The results of this report suggest that the Dnmt inhibitor 5-aza may promote hair cell regeneration in a chemically-deafened mouse model.
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