Evidence map›Paper›PMID 31142734›Full record

ArticleCell death & disease2019

Selective cell death of latently HIV-infected CD4

Gang Zhang, Brian T Luk, Xiaoli Wei, Grant R Campbell, Ronnie H Fang, Liangfang Zhang, Stephen A Spector

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Autophagy: Regulator of cell death.Cell death & disease · 2023
    Review
  13. Article
  14. Autosis as a selective type of cell death.Frontiers in cell and developmental biology · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Mitochondria Related Cell Death Modalities and Disease.Frontiers in cell and developmental biology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gang ZhangDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3109-915X
Brian T LukDepartment of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Xiaoli WeiDepartment of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Grant R CampbellDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3927-1994
Ronnie H FangDepartment of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Liangfang ZhangDepartment of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Stephen A SpectorDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. saspector@ucsd.edu.ORCID http://orcid.org/0000-0002-1882-4855
University of California San Diego · US

Funding

LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Sharon A Nachman · 2011 to 2026
$278.1M
Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGUM1AI068616 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sean Scott Brummel, Marlene Ann Cooper · 2011 to 2026
$155.6M
LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
University of California, San Diego Clinical Trial UnitUM1AI069536 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEPHEN A SPECTOR · 2012 to 2026
$34.0M
Nanopeptide Targeting of HIV-CNS Reservoirs without ReactivationR01NS104015 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2017 to 2021
$2.9M
Modulating Autophagy to Eradicate HIV-1 from CNS ReservoirsR01NS084912 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2013 to 2017
$1.9M
NIAID NIH HHS UM1 AI068616NIAID NIH HHS UM1 AI068632NIAID NIH HHS UM1 AI069536NIAID NIH HHS UM1 AI106716NINDS NIH HHS R01 NS084912NINDS NIH HHS R01 NS104015
6 · The paper itself

Abstract

Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discontinuation of antiretrovirals results in viral reactivation and disease progression. A major reservoir of HIV latent infection resides in resting central memory CD4

Indexed as

Amino Acid SequenceApoptosisAutophagy-Related Protein 5Autophagy-Related Protein 7Beclin-1CD4-Positive T-LymphocytesHIV-1HIV InfectionsHumansLeukocytes, MononuclearNanoparticlesPeptidesRNA InterferenceRNA, Small InterferingSodium-Potassium-Exchanging ATPasetat Gene Products, Human Immunodeficiency VirusATG5 protein, humanATG7 protein, humanAutophagy-Related Protein 5Autophagy-Related Protein 7Beclin-1PeptidesRNA, Small InterferingSodium-Potassium-Exchanging ATPasetat Gene Products, Human Immunodeficiency Virusviral FLIP protein, Human herpesvirus 8Viral Proteins

Identifiers

PMID31142734
PMCPMC6541658
OpenAlexW2946922275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.