Evidence map›Paper›PMID 31142733›Full record

ArticleCell death & disease2019

Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis.

Hendrik Folkerts, Albertus T Wierenga, Fiona A van den Heuvel, Roy R Woldhuis, Darlyne S Kluit, Jennifer Jaques, Jan Jacob Schuringa, Edo Vellenga

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  10. International journal of molecular sciences · 2023
    Article
  11. Article
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  13. Autophagy in acute myeloid leukemia: a paradoxical role in chemoresistance.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  14. Article
  15. Article
  16. The dual role of autophagy in acute myeloid leukemia.Journal of hematology & oncology · 2022
    Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hendrik FolkertsDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Albertus T WierengaDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Fiona A van den HeuvelDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Roy R WoldhuisDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Darlyne S KluitDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jennifer JaquesDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jan Jacob SchuringaDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8452-8555
Edo VellengaDepartment of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.vellenga@umcg.nl.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vacuole membrane protein (VMP1) is a putative autophagy protein, which together with Beclin-1 acts as a molecular switch in activating autophagy. In the present study the role of VMP1 was analysed in CD34

Indexed as

AutophagyAnimalsAntigens, CD34Antineoplastic AgentsApoptosisBridged Bicyclo Compounds, HeterocyclicCell Cycle CheckpointsFemaleFetal BloodHumansLeukemia, Myeloid, AcuteLeukocytes, MononuclearMembrane ProteinsMiceMice, TransgenicMitochondriaAntigens, CD34Antineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicMembrane ProteinsRNA, Small InterferingSequestosome-1 ProteinSQSTM1 protein, humanSulfonamidesvenetoclaxVMP1 protein, human

Identifiers

PMID31142733
PMCPMC6541608
OpenAlexW2947575755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.