Evidence map›Paper›PMID 31142674›Full record

ArticleJournal of virology2019

A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication.

Stuart Weston, Krystal L Matthews, Rachel Lent, Alexandra Vlk, Rob Haupt, Tami Kingsbury, Matthew B Frieman

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. NADThe Journal of general virology · 2026
    Review
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  11. Review
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  13. The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Considerations for Gut Microbiota and Probiotics in Patients with Diabetes Amidst the Covid-19 Pandemic: A Narrative Review.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2020
    Review
  15. Article
  16. Using Yeast to Identify Coronavirus-Host Protein Interactions.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stuart WestonDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Krystal L MatthewsDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Rachel LentDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Alexandra VlkDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Rob HauptDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Tami KingsburyCenter for Stem Cell Biology and Regenerative Medicine, Marlene and Stewart Greenebaum Cancer Center, Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Matthew B FriemanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA MFrieman@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral proteins must intimately interact with the host cell machinery during virus replication. Here, we used the yeast

Indexed as

Host-Pathogen InteractionsVirus ReplicationCell LineCells, CulturedCoronavirus InfectionsGene SilencingHumansMiddle East Respiratory Syndrome CoronavirusPhenotypeProtein BindingRNA InterferenceSaccharomyces cerevisiaeSirtuin 1Viral Structural ProteinsYeastsSIRT1 protein, humanSirtuin 1Viral Structural Proteinshost-virus interactionMERS-CoVORF4aSIRT1suppressor screenvirus-host interactionyeast

Identifiers

PMID31142674
PMCPMC6675885
OpenAlexW2946801855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.