Evidence map›Paper›PMID 31142635›Full record

ReviewNeurology2019

CNS small vessel disease: A clinical review.

Rocco J Cannistraro, Mohammed Badi, Benjamin H Eidelman, Dennis W Dickson, Erik H Middlebrooks, James F Meschia

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05052788 (Optical Coherence Tomography Angiography in Patients With Cerebral Small Vessel Disease.), which is not on this map. Cited by 387 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
387citing papers in PubMed, 7 pooled it
32.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05052788 unknown statusnot on this mapstarted 2021, after this paper: background citation

Optical Coherence Tomography Angiography in Patients With Cerebral Small Vessel Disease.

TypeobservationalSponsorAin Shams UniversityRan2021 to 2022Enrolled60ConditionsCerebral Small Vessel Disease and OCT AngioArmsOptical coherence tomography angiography
3 · Its place in the literature

Who cites it

387 citing papers in PubMed, 7 syntheses or guidelines pooled it, 615 citations in OpenAlex.

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  7. Sporadic cerebral small vessel disease and cognitive decline in healthy older adults: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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  8. Differential impact of cumulative cerebral small-vessel disease burden on ischemic versus hemorrhagic stroke recurrence in hemorrhage-prone patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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327 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rocco J CannistraroFrom the Department of Neurology (R.J.C., M.B., B.H.E., J.F.M.), Department of Laboratory Medicine and Pathology (D.W.D.), Department of Neuroscience (D.W.D.), and Department of Radiology (E.H.M.), Mayo Clinic, Jacksonville, FL.
Mohammed BadiFrom the Department of Neurology (R.J.C., M.B., B.H.E., J.F.M.), Department of Laboratory Medicine and Pathology (D.W.D.), Department of Neuroscience (D.W.D.), and Department of Radiology (E.H.M.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0003-2647-6114
Benjamin H EidelmanFrom the Department of Neurology (R.J.C., M.B., B.H.E., J.F.M.), Department of Laboratory Medicine and Pathology (D.W.D.), Department of Neuroscience (D.W.D.), and Department of Radiology (E.H.M.), Mayo Clinic, Jacksonville, FL.
Dennis W DicksonFrom the Department of Neurology (R.J.C., M.B., B.H.E., J.F.M.), Department of Laboratory Medicine and Pathology (D.W.D.), Department of Neuroscience (D.W.D.), and Department of Radiology (E.H.M.), Mayo Clinic, Jacksonville, FL.
Erik H MiddlebrooksFrom the Department of Neurology (R.J.C., M.B., B.H.E., J.F.M.), Department of Laboratory Medicine and Pathology (D.W.D.), Department of Neuroscience (D.W.D.), and Department of Radiology (E.H.M.), Mayo Clinic, Jacksonville, FL.
James F MeschiaFrom the Department of Neurology (R.J.C., M.B., B.H.E., J.F.M.), Department of Laboratory Medicine and Pathology (D.W.D.), Department of Neuroscience (D.W.D.), and Department of Radiology (E.H.M.), Mayo Clinic, Jacksonville, FL. meschia.james@mayo.edu.
Jacksonville College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CNS small vessel disease (CSVD) causes 25% of strokes and contributes to 45% of dementia cases. Prevalence increases with age, affecting about 5% of people aged 50 years to almost 100% of people older than 90 years. Known causes and risk factors include age, hypertension, branch atheromatous disease, cerebral amyloid angiopathy, radiation exposure, immune-mediated vasculitides, certain infections, and several genetic diseases. CSVD can be asymptomatic; however, depending on location, lesions can cause mild cognitive dysfunction, dementia, mood disorders, motor and gait dysfunction, and urinary incontinence. CSVD is diagnosed on the basis of brain imaging biomarkers, including recent small subcortical infarcts, white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and cerebral atrophy. Advanced imaging modalities can detect signs of disease even earlier than current standard imaging techniques. Diffusion tensor imaging can identify altered white matter connectivity, and blood oxygenation level-dependent imaging can identify decreased vascular reactivity. Pathogenesis is thought to begin with an etiologically specific insult, with or without genetic predisposition, which results in dysfunction of the neurovascular unit. Uncertainties regarding pathogenesis have delayed development of effective treatment. The most widely accepted approach to treatment is to intensively control well-established vascular risk factors, of which hypertension is the most important. With better understanding of pathogenesis, specific therapies may emerge. Early identification of pathologic characteristics with advanced imaging provides an opportunity to forestall progression before emergence of symptoms.

Indexed as

Antihypertensive AgentsCADASILCerebral Amyloid AngiopathyCerebral Small Vessel DiseasesDementiaDiffusion Magnetic Resonance ImagingHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMagnetic Resonance ImagingPlatelet Aggregation InhibitorsStroke, LacunarAntihypertensive AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation Inhibitors

Identifiers

PMID31142635
PMCPMC6598791
OpenAlexW2947924379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.