Evidence map›Paper›PMID 31142601›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

CRTAM Shapes the Gut Microbiota and Enhances the Severity of Infection.

Araceli Perez-Lopez, Sean-Paul Nuccio, Irina Ushach, Robert A Edwards, Rachna Pahu, Steven Silva, Albert Zlotnik, Manuela Raffatellu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Araceli Perez-LopezDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-5399-1958
Sean-Paul NuccioDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-9683-9278
Irina UshachInstitute for Immunology, University of California, Irvine, Irvine, CA 92697.
Robert A EdwardsDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0001-9145-382X
Rachna PahuDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697.
Steven SilvaDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-8529-4535
Albert ZlotnikInstitute for Immunology, University of California, Irvine, Irvine, CA 92697.ORCID 0000-0003-0030-9350
Manuela RaffatelluDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093; manuelar@ucsd.edu.ORCID 0000-0001-6487-4215
University of California, Irvine · USUniversity of California San Diego · US

Funding

Nutritional immunity during Salmonella infectionR01AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA · 2016 to 2020
$1.9M
Development of siderophore-based vaccines against non-typhoidal Salmonella infectionR01AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2015 to 2019
$1.9M
Nutritional immunity during Salmonella infectionR37AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Manuela Raffatellu · 2023 to 2026
$1.8M
The new chemokine CCL28 and its role during Salmonella infectionR21AI121928 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA, ZLOTNIK, ALBERT · 2016 to 2017
$425k
Siderophore-based antibiotics: consequences for the microbiota and bacterial pathogensR21AI126465 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2016 to 2017
$404k
Harnessing iron acquisition to hinder enterobacterial pathogenesisR56AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2022 to 2022
$400k
NIAID NIH HHS R01 AI114625NIAID NIH HHS R01 AI126277NIAID NIH HHS R21 AI121928NIAID NIH HHS R21 AI126465NIAID NIH HHS R37 AI126277NIAID NIH HHS R56 AI114625
6 · The paper itself

Abstract

Gut lymphocytes and the microbiota establish a reciprocal relationship that impacts the host immune response. Class I-restricted T cell-associated molecule (CRTAM) is a cell adhesion molecule expressed by intraepithelial T cells and is required for their retention in the gut. In this study, we show that CRTAM expression affects gut microbiota composition under homeostatic conditions. Moreover,

Indexed as

AnimalsFemaleGastrointestinal MicrobiomeImmunoglobulinsInflammationIntestinesMaleMiceSalmonellaSalmonella InfectionsTh17 CellsT-Lymphocytesclass-I restricted T cell-associated moleculeImmunoglobulins

Identifiers

PMID31142601
PMCPMC6615957
OpenAlexW2947280445

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.