ArticleDiabetes care2019
Trends of Nontraumatic Lower-Extremity Amputation in End-Stage Renal Disease and Diabetes: United States, 2000-2015.
Article in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Diabetic Foot Ulceration in Dialysis-Dependent End-Stage Kidney Disease: A Systematic Review of Epidemiology, Clinical Outcomes and Mortality Risk.Diabetes/metabolism research and reviews · 2026Pooled it
- Health service organisation impact on lower extremity amputations in people with type 2 diabetes with foot ulcers: systematic review and meta-analysis.Acta diabetologica · 2021Pooled it
- Synergistic effects of diabetic neuropathy and kidney function decline on second metatarsal skeletal health and foot function: a pilot study.JBMR plus · 2026Article
- Clinical and psychological adjustment to prosthesis use in lower-limb amputees: focus on differences between traditional and high-technology rehabilitation.Frontiers in rehabilitation sciences · 2026Article
- Estimating the Risk of Lower Extremity Complications in Adults Newly Diagnosed With Diabetic Polyneuropathy: Retrospective Cohort Study.JMIR diabetes · 2025Article
- Comparative Analysis of Lower Back Pain and Phantom Pain in Unilateral Lower Limb Amputees: A Study on Amputee Football Players vs. Non-Athletes.Medicina (Kaunas, Lithuania) · 2024Article
- Development and validation of a brief diabetic foot risk screening scale for diabetic patients.International journal of nursing studies advances · 2024Article
- Temporal Trends in Distal Symmetric Polyneuropathy in Type 2 Diabetes: The Fremantle Diabetes Study.The Journal of clinical endocrinology and metabolism · 2024Observational
- Renal function is highly associated with podiatric risk in diabetic patients.Clinical kidney journal · 2023Article
- Improving health outcomes of people with diabetes: target setting for the WHO Global Diabetes Compact.Lancet (London, England) · 2023Article
- Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice.Nature reviews. Endocrinology · 2023Review
- Changes in excess mortality among adults with diabetes-related end-stage kidney disease: a comparison between the USA and Australia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- CT-Angiography-Based Outcome Prediction on Diabetic Foot Ulcer Patients: A Statistical Learning Approach.Diagnostics (Basel, Switzerland) · 2022Article
- Narrative Review of the Relationship Between CKD and Diabetic Foot Ulcer.Kidney international reports · 2022Review
- Trends of Non-Traumatic Lower-Extremity Amputation and Type 2 Diabetes: Spain, 2001-2019.Journal of clinical medicine · 2022Article
- Micro- and macrovascular complications and risk factors for foot ulceration and amputation in individuals receiving dialysis with and without diabetes.Endocrinology, diabetes & metabolism · 2022Article
- Adherence to General Diabetes and Foot Care Processes, with Prompt Referral, Are Associated with Amputation-Free Survival in People with Type 2 Diabetes and Foot Ulcers: A Scottish National Registry Analysis.Journal of diabetes research · 2022Article
- Long-term mortality among kidney transplant recipients with and without diabetes: a nationwide cohort study in the USA.BMJ open diabetes research & care · 2021Article
- Temporal Trends in Incidence Rates of Lower Extremity Amputation and Associated Risk Factors Among Patients Using Veterans Health Administration Services From 2008 to 2018.JAMA network open · 2021Article
- Family history of diabetes is associated with diabetic foot complications in type 2 diabetes.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveNontraumatic lower-extremity amputation (NLEA) is a complication of end-stage renal disease (ESRD) and diabetes. Although recent data show that NLEA rates in the U.S. ESRD population are declining overall, trends in diabetes and diabetes subgroups remain unclear. RESEARCH DESIGN AND
methodsWe estimated annual rates of NLEA hospitalizations during 2000-2015 among >2 million adults (≥18 years) with ESRD from the U.S. Renal Data System. Age, sex, and race-adjusted NLEA rates were stratified by diabetes status, age, sex, race, and level of amputation (toe, foot, below the knee, and above the knee). Time trends were assessed using Joinpoint regression with annual percent changes (APC) reported.
resultsAmong adults with diabetes, NLEA rates declined 43.8% between 2000 and 2013 (from 7.5 to 4.2 per 100 person-years; APC -4.9,
conclusionsDespite an initial period of decline, this analysis documents a stall in progress in NLEA trends in recent years in a high-risk population with both ESRD and diabetes. Increased attention to preventive foot care in the ESRD population should be considered, particularly for those with diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.