Evidence map›Paper›PMID 31142450›Full record

ArticleBMJ (Clinical research ed.)2019

Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study.

Anaïs Rico-Campà, Miguel A Martínez-González, Ismael Alvarez-Alvarez, Raquel de Deus Mendonça, Carmen de la Fuente-Arrillaga, Clara Gómez-Donoso, Maira Bes-Rastrollo

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02669602 (Dynamic Mediterranean Prospective Cohort), which is not on this map. Cited by 245 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02669602 enrolling by invitationnot on this map

Dynamic Mediterranean Prospective Cohort: the SUN Project

TypeobservationalSponsorClinica Universidad de Navarra, Universidad de NavarraRan1999 to 2075Enrolled22,500ConditionsLifestyle, Chronic Disease, Dietary Habits
3 · Its place in the literature

Who cites it

245 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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185 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anaïs Rico-CampàDepartment of Preventive Medicine and Public Health, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Miguel A Martínez-GonzálezDepartment of Preventive Medicine and Public Health, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Ismael Alvarez-AlvarezDepartment of Preventive Medicine and Public Health, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Raquel de Deus MendonçaDepartment of Preventive Medicine and Public Health, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Carmen de la Fuente-ArrillagaDepartment of Preventive Medicine and Public Health, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Clara Gómez-DonosoDepartment of Preventive Medicine and Public Health, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Maira Bes-RastrolloDepartment of Preventive Medicine and Public Health, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain mbes@unav.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between consumption of ultra-processed foods and all cause mortality.

designProspective cohort study.

settingSeguimiento Universidad de Navarra (SUN) cohort of university graduates, Spain 1999-2018.

participants19 899 participants (12 113 women and 7786 men) aged 20-91 years followed-up every two years between December 1999 and February 2014 for food and drink consumption, classified according to the degree of processing by the NOVA classification, and evaluated through a validated 136 item food frequency questionnaire.

main outcome measureAssociation between consumption of energy adjusted ultra-processed foods categorised into quarters (low, low-medium, medium-high, and high consumption) and all cause mortality, using multivariable Cox proportional hazard models.

results335 deaths occurred during 200 432 persons years of follow-up. Participants in the highest quarter (high consumption) of ultra-processed foods consumption had a higher hazard for all cause mortality compared with those in the lowest quarter (multivariable adjusted hazard ratio 1.62, 95% confidence interval 1.13 to 2.33) with a significant dose-response relation (P for linear trend=0.005). For each additional serving of ultra-processed foods, all cause mortality relatively increased by 18% (adjusted hazard ratio 1.18, 95% confidence interval 1.05 to 1.33).

conclusionsA higher consumption of ultra-processed foods (>4 servings daily) was independently associated with a 62% relatively increased hazard for all cause mortality. For each additional serving of ultra-processed food, all cause mortality increased by 18%. STUDY REGISTRATION: ClinicalTrials.gov NCT02669602.

Indexed as

EatingFast FoodsMortalityAdultAgedAged, 80 and overCause of DeathCohort StudiesCorrelation of DataFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsProspective Studies

Identifiers

PMID31142450
PMCPMC6538973

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.