Evidence map›Paper›PMID 31142401›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2019

Analgesia during Monkeypox Virus Experimental Challenge Studies in Prairie Dogs (

Christina L Hutson, Nadia Gallardo-Romero, Darin S Carroll, Johanna S Salzer, Jessica D Ayers, Jeff B Doty, Christine M Hughes, Yoshi Nakazawa, Paul Hudson, Nishi Patel and 3 more

Open access · greenAbstract readClinical Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Monkeypox: Some Keys to Understand This Emerging Disease.Animals : an open access journal from MDPI · 2022
    Review
  10. Article
  11. Article
  12. Pharmacokinetic Profiles of Gabapentin after Oral and Subcutaneous Administration in Black-tailed Prairie Dogs (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Christina L HutsonCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia; The University of Georgia, Athens, Georgia; Georgia;, Email: zuu6@cdc.gov.
Nadia Gallardo-RomeroCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Darin S CarrollCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Johanna S SalzerCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Jessica D AyersCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Jeff B DotyCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Christine M HughesCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Yoshi NakazawaCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Paul HudsonCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Nishi PatelCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
M S KecklerCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Victoria A OlsonCenters for Disease Control and Prevention, The University of Georgia, Athens, Georgia.
Tamas NagyThe University of Georgia, Athens, Georgia.
University of Georgia · USCenters for Disease Control and Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because human patients with monkeypox virus (MPXV) infection report painful symptoms, it is reasonable to assume that animals infected with MPXV experience some degree of pain. Understanding whether and how analgesics affect MPXV disease progression is crucial when planning in vivo challenge experiments. In the current study, we challenged prairie dogs with a low dose (4 ×10³ pfu) of MPXV and treated with meloxicam (NSAID) or buprenorphine (opioid); control animals did not receive analgesia or received analgesia without MPXV challenge. Subsets of animals from each group were serially euthanized during the course of the study. Disease progression and viral kinetics were similar between groups, but MXPVinfected, meloxicam-treated animals showed increasing trends of morbidity and mortality compared with other groups. Differences between no-analgesia MPXV-infected control animals and MPXV-infected animals treated with buprenorphine were minimal. The findings in the current study allow more informed decisions concerning the use of analgesics during experimental MPXV challenge studies, thereby improving animal welfare. In light of these findings, we have modified our pain scale for this animal model to include the use of buprenorphine for pain relief when warranted after MPXV challenge.

Indexed as

AnalgesiaBuprenorphineMeloxicamMpox, MonkeypoxPainPain ManagementSciuridaeAnalgesics, OpioidAnimalsAnti-Inflammatory Agents, Non-SteroidalDisease Models, AnimalFemaleMonkeypox virusAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalBuprenorphineMeloxicam

Identifiers

PMID31142401
PMCPMC6643093
OpenAlexW2947040225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.