Evidence map›Paper›PMID 31142368›Full record

ArticleGenome biology2019

Mouse microbiomes: overlooked culprits of experimental variability.

Maria-Luisa Alegre

Abstract readComment
In one paragraph

Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Tutorial: Microbiome studies in drug metabolism.Clinical and translational science · 2022
    Article
  5. Article
  6. Effect of Caging onMicroorganisms · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Influence of the Host and Parasite Strain on the Immune Response DuringFrontiers in cellular and infection microbiology · 2020
    Review
  16. Impact of the microbiota on solid organ transplant rejection.Current opinion in organ transplantation · 2019
    Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Maria-Luisa AlegreDepartment of Medicine, Section of Rheumatology, University of Chicago, South Maryland Avenue, Chicago, IL, 60637, USA. malegre@medicine.bsd.uchicago.edu.

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Impact of Microbiota on Alloimmune Responses in TransplantationR01AI115716 · NIAID · UNIVERSITY OF CHICAGO · PI ALEGRE, MARIA-LUISA · 2015 to 2024
$4.3M
The microbiota and allograft rejection: novel investigations into the consequences of obesityU01AI132898 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEGRE, MARIA-LUISA, PERKINS, DAVID LINN · 2017 to 2021
$2.3M
NIAID NIH HHS R01 AI115716NIAID NIH HHS U01 AI132898NIDDK NIH HHS P30 DK042086
6 · The paper itself

Abstract

Recent studies have found differences between almost genetically identical mice that were attributable to differences between their microbiomes. One example of mice from different vendors having different susceptibilities to infection by Salmonella enterica serovar Typhimurium has just been published in Nature Microbiology.

Indexed as

MicrobiotaSalmonella Infections, AnimalAnimalsEnterobacteriaceaeMiceSalmonella typhimurium

Identifiers

PMID31142368
PMCPMC6540381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.