Evidence map›Paper›PMID 31142293›Full record

ArticleBMC endocrine disorders2019

Association between Hashimoto's thyroiditis and papillary thyroid carcinoma: a retrospective analysis of 305 patients.

Giuseppa Graceffa, Renato Patrone, Salvatore Vieni, Silvia Campanella, Sergio Calamia, Iole Laise, Giovanni Conzo, Mario Latteri, Calogero Cipolla

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In one paragraph

Article in BMC endocrine disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  7. The Role of Lipid Metabolism Disorders in the Development of Thyroid Cancer.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuseppa GraceffaDepartment of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro, 129 90127, Palermo, Italy.
Renato PatroneDivision of General and Oncologic Surgery - Department of Cardiothoracic Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.
Salvatore VieniDepartment of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro, 129 90127, Palermo, Italy.
Silvia CampanellaDepartment of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro, 129 90127, Palermo, Italy.
Sergio CalamiaDepartment of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro, 129 90127, Palermo, Italy.
Iole LaiseDepartment of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro, 129 90127, Palermo, Italy.
Giovanni ConzoDivision of General and Oncologic Surgery - Department of Cardiothoracic Sciences, University of Campania "Luigi Vanvitelli", Via Pansini 5, 80131, Naples, Italy.
Mario LatteriDepartment of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro, 129 90127, Palermo, Italy.
Calogero CipollaDepartment of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro, 129 90127, Palermo, Italy. calogero.cipolla@unipa.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is a controversial question that is still under debate, its pathological significance and the eventual clinical implications of this association remaining unclear.

methodsThe data regarding 305 patients were retrospectively analyzed. The patients were divided in two different groups. A first group made up of 142 patients undergoing surgery for differentiated thyroid carcinoma was compared to a control group of 142 analogous subjects operated for normofunctioning goiter. A second group was made up of 163 patients who had undergone total thyroidectomy (TT) with pre-operative diagnosis of HT.

resultsIn the first group of patients an association with HT was found in 28,6% of the patients with final histopathological diagnosis of PTC versus 7,7% of the patients with histopathological diagnosis of multinodular goiter, which was a significant difference (p <  0.001). In the second group, the association with PTC was found in 43 (40,2%) cases of HT nodular variant and in 3 cases (8,1%) of HT diffuse variant (p <  0.001).

conclusionsThe relationship between HT and PTC is still far from clear and represents an unresolved issue. Our own study has underlined the frequent coexistence of these two pathologies, an aspect not to be neglected in clinical practice. Patients receiving HT diagnosis should undergo careful follow-up and, especially those with the nodular variant, should undergo a frequent both clinical and cytological evaluation of the nodular lesions, taking always into great consideration the surgical approach of total thyroidectomy.

Indexed as

AdolescentAdultAgedAged, 80 and overFemaleFollow-Up StudiesHashimoto DiseaseHumansMaleMiddle AgedPrognosisRetrospective StudiesThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultHashimoto’s thyroiditisPapillary thyroid carcinoma

Identifiers

PMID31142293
PMCPMC6541562

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.