Evidence map›Paper›PMID 31142266›Full record

ArticleBMC bioinformatics2019

Pairwise visual comparison of small RNA secondary structures with base pair probabilities.

Serge Léger, Maria Beatriz Walter Costa, Dan Tulpan

Abstract read
In one paragraph

Article in BMC bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Evolutionary Conservation of RNA Secondary Structure.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Serge LégerDigital Technologies Research Center, National Research Council Canada, 100 des Aboiteaux St, Moncton, NB, E1A7R1, Canada.
Maria Beatriz Walter CostaDepartment of Computer Science, TFome Research Group, Bioinformatics Group, Interdisciplinary Center of Bioinformatics, University of Leipzig, Härtelstrasse 16-18, D-04107, Leipzig, Germany.
Dan TulpanDepartment of Animal Biosciences, Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, Ontario, Canada. dtulpan@uoguelph.ca.ORCID http://orcid.org/0000-0003-1100-646X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPredicted RNA secondary structures are typically visualized using dot-plots for base pair binding probabilities and planar graphs for unique structures, such as the minimum free energy structure. These are however difficult to analyze simultaneously.

resultsThis work introduces a compact unified view of the most stable conformation of an RNA secondary structure and its base pair probabilities, which is called the Circular Secondary Structure Base Pairs Probabilities Plot (CS

conclusionsUsing circular diagrams and colour and weight-coded arcs, we demonstrate how a single image can replace the state-of-the-art dual representations (dot-plots and minimum free energy structures) for base-pair probabilities of RNA secondary structures while allowing efficient exploration and comparison of different RNA conformations via a web server front end. With that, we provide the community, especially the biologically oriented, with an intuitive tool for ncRNA visualization. Web-server: https://nrcmonsrv01.nrc.ca/cs2bp2plot.

Indexed as

Base PairingNucleic Acid ConformationProbabilityAlgorithmsCRISPR-Cas SystemsEvolution, MolecularHumansRNARNA, Guide, CRISPR-Cas SystemsVirulenceYersiniaRNARNA, Guide, CRISPR-Cas Systems

Identifiers

PMID31142266
PMCPMC6542128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.