ReviewBiological research for nursing2019
Biobehavioral Mechanisms Associated With Nonhealing Wounds and Psychoneurologic Symptoms (Pain, Cognitive Dysfunction, Fatigue, Depression, and Anxiety) in Older Individuals With Chronic Venous Leg Ulcers.
Review in Biological research for nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pain in persons with chronic venous leg ulcers: A systematic review and meta-analysis.International wound journal · 2020Pooled it
- Healing beyond the wound: social determinants in chronic vascular care. Perspectives from clinical practice.Frontiers in sociology · 2026Article
- A Review of Chronic Wounds and Their Impact on Negative Affect, Cognition, and Quality of Life.International wound journal · 2025Review
- The Association of Systemic Inflammation, Wound Bioburden and Total Bacterial Counts With Healing Outcomes in Older Adults With Chronic Venous Leg Ulcers.International wound journal · 2025Article
- Social Isolation, Loneliness, Anxiety, and Quality of Life in a Chronic Ulcer Population With and Without Stigma: An Observational Trial.Journal of patient experience · 2025Article
- Associations Among Wound-Related Factors Including Biofilm, Wound-Related Symptoms and Systemic Inflammation in Older Adults with Chronic Venous Leg Ulcers.Advances in wound care · 2024Observational
- Sleep, Fatigue, and Inflammatory Biomarkers in Older Adults with Chronic Venous Leg Ulcers Receiving Intensive Outpatient Wound Care.Advances in wound care · 2024Article
- The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers.International wound journal · 2023Article
- Review
- Potential predictors of quality of life in patients with venous leg ulcers: A cross-sectional study in Taiwan.International wound journal · 2022Article
- Healing of a chronic ulcer of the lower limb of venous origin with fresh human amniochorionic membrane allograftBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Chronic wounds: Treatment consensus.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Multidimensional Pain Characteristics in Older Adults with Chronic Venous Leg Ulcers.Advances in wound care · 2021Observational
- Metabolomics: Impact of Comorbidities and Inflammation on Sickness Behaviors for Individuals with Chronic Wounds.Advances in wound care · 2021Review
- An observational study protocol to explore loneliness and systemic inflammation in an older adult population with chronic venous leg ulcers.BMC geriatrics · 2021Article
- The Association between Cognitive Impairment and Diabetic Foot Care: Role of Neuropathy and Glycated Hemoglobin.Pathophysiology : the official journal of the International Society for Pathophysiology · 2020Article
- [Quality of life in patients with chronic wounds].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020Review
- Heritable Tissue-Specific Gene Expression Associates With Chronic Wound Microbial Species.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The prevalence and incidence of chronic venous leg ulcers (CVLUs) are increasing worldwide, as are the associated financial costs. Although it has long been known that their underlying etiology is venous insufficiency, the molecular aspects of healing versus nonhealing, as well as the psychoneurologic symptoms (PNS; pain, cognitive dysfunction, fatigue, depression, and anxiety) associated with CVLUs remain understudied. In this biobehaviorally focused review, we aim to elucidate the complex mechanisms that link the biological and molecular aspects of CLVUs with their PNS. Innovations in "omics" research have increased our understanding of important wound microenvironmental factors (e.g., inflammation, microbial pathogenic biofilm, epigenetic processes) that may adversely alter the wound bed's molecular milieu so that microbes evade immune detection. Although these molecular factors are not singularly responsible for wound healing, they are major components of wound development, nonhealing, and PNS that, until now, have not been amenable to systematic study, especially over time. Further, this review explores our current understanding of the molecular mechanisms by which the immune activation that contributes to the development and persistence of CVLUs also leads to the development, persistence, and severity of wound-related PNS. We also make recommendations for future research that will expand the field of biobehavioral wound science. Biobehavioral research that focuses on the interrelated mechanisms of PNS will lead to symptom-management interventions that improve quality of life for the population burdened by CVLUs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.