Evidence map›Paper›PMID 31141941›Full record

ArticleInternational journal of molecular sciences2019

Thymoquinone-Induced Tristetraprolin Inhibits Tumor Growth and Metastasis through Destabilization of MUC4 mRNA.

Se-Ra Lee, Jeong-Yeon Mun, Mi-So Jeong, Hyun-Hee Lee, Yun-Gil Roh, Won-Tae Kim, Min-Hye Kim, Jeonghoon Heo, Yung Hyun Choi, Su Jin Kim and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Se-Ra LeeDepartment of Biological Science, Dong-A University, Busan 49315, Korea. srlee@kbiohealth.kr.
Jeong-Yeon MunDepartment of Biological Science, Dong-A University, Busan 49315, Korea. moonmihye90@hanmail.net.
Mi-So JeongDepartment of Biological Science, Dong-A University, Busan 49315, Korea. dkwl523@hanmail.net.
Hyun-Hee LeeDepartment of Biological Science, Dong-A University, Busan 49315, Korea. hyunhee517@hotmail.com.
Yun-Gil RohDepartment of Biological Science, Dong-A University, Busan 49315, Korea. royunkil@gmail.com.
Won-Tae KimDepartment of Biological Science, Dong-A University, Busan 49315, Korea. kimwt33@nate.com.
Min-Hye KimDepartment of Biological Science, Dong-A University, Busan 49315, Korea. kmhmary93@naver.com.
Jeonghoon HeoDepartments of Molecular Biology and Immunology, College of Medicine, Kosin University, Busan 49267, Korea. jeonghoonheo@kosin.ac.kr.
Yung Hyun ChoiDepartment of Biochemistry, College of Oriental Medicine, Anti-Aging Research Center, Dongeui University, Busan 47227, Korea. choiyh@deu.ac.kr.ORCID 0000-0002-1454-3124
Su Jin KimDepartment of Pathology, College of Medicine, Dong-A University, Busan 49315, Korea. tina_branf@naver.com.
Hee-Jae ChaDepartment of Parasitology and Genetics, Kosin University College of Medicine, Busan 602-702, Korea. hcha@kosin.ac.kr.ORCID 0000-0002-6963-2685
Mira JunDepartment of Food Science and Nutrition, Dong-A University, Busan 49315, Korea. mjun@dau.ac.kr.
Sun-Hee LeemDepartment of Biological Science, Dong-A University, Busan 49315, Korea. shleem@dau.ac.kr.
Dong-A University · KRKosin University · KRDong-Eui University · KROsong Medical Innovation Foundation · KR

Funding

Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare HI16C1866National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT & Future Planning 2017R1A2B2007836
6 · The paper itself

Abstract

Tristetraprolin (TTP), a well-characterized AU-rich element (ARE) binding protein, functions as a tumor suppressor gene. The purpose of this study was to investigate whether a bioactive substance derived from a natural medicinal plant affects the induction of TTP and to elucidate its mechanism. We examined the effects of natural bioactive materials including Resveratrol (RSV), thymoquinone (TQ) and curcumin on the expression of TTP in cancer cell. TQ derived from a natural plant

Indexed as

AnimalsAntineoplastic AgentsBenzoquinonesCell LineCell MovementCell ProliferationFemaleHumansMCF-7 CellsMiceMice, Inbred C57BLMucin-4Neoplasms, ExperimentalRNA, MessengerRNA StabilityTristetraprolinAntineoplastic AgentsBenzoquinonesMuc4 protein, mouseMucin-4RNA, MessengerthymoquinoneTristetraprolinAREbinding proteinbioactive substanceMUC4TQTTP

Identifiers

PMID31141941
PMCPMC6600862
OpenAlexW2947338521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.