Evidence map›Paper›PMID 31141939›Full record

ArticleMolecules (Basel, Switzerland)2019

Encapsulation of Thermo-Sensitive Lauric Acid in Silica Shell: A Green Derivate for Chemo-Thermal Therapy in Breast Cancer Cell.

Valeria De Matteis, Mariafrancesca Cascione, Maria Luisa De Giorgi, Stefano Leporatti, Rosaria Rinaldi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Valeria De MatteisDipartimento di Matematica e Fisica "E. De Giorgi", Università del Salento, Via per Arnesano, 73100 Lecce, Italy. valeria.dematteis@unisalento.it.
Mariafrancesca CascioneDipartimento di Matematica e Fisica "E. De Giorgi", Università del Salento, Via per Arnesano, 73100 Lecce, Italy. mariafrancesca.cascione@unisalento.it.
Maria Luisa De GiorgiDipartimento di Matematica e Fisica "E. De Giorgi", Università del Salento, Via per Arnesano, 73100 Lecce, Italy. marialuisa.degiorgi@le.infn.it.
Stefano LeporattiCNR Nanotec-Istituto di Nanotecnologia, via Monteroni, c/o Campus Ecotekne, 73100 Lecce, Italy. stefano.leporatti@nanotec.cnr.it.ORCID 0000-0001-5912-7565
Rosaria RinaldiDipartimento di Matematica e Fisica "E. De Giorgi", Università del Salento, Via per Arnesano, 73100 Lecce, Italy. ross.rinaldi@unisalento.it.
University of Salento · ITIstituto Nanoscienze · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lauric acid is a green derivate that is abundant in some seeds such as coconut oil where it represents the most relevant fatty acid. Some studies have emphasized its anticancer effect due to apoptosis induction. In addition, the lauric acid is a Phase Change Material having a melting temperature of about 43.2 °C: this property makes it a powerful tool in cancer treatment by hyperthermal stress, generally induced at 43 °C. However, the direct use of lauric acid can have some controversial effects, and it can undergo degradation phenomena in the extracellular environment. For this reason, we have encapsulated lauric acid in a silica shell with a one-step and reproducible synthetic route in order to obtain a monodispersed SiO

Indexed as

Drug CompoundingTemperatureActinsApoptosisBreast NeoplasmsCalorimetry, Differential ScanningCell NucleusCell SurvivalDynamic Light ScatteringFemaleHumansLauric AcidsMCF-7 CellsNanoparticlesReactive Oxygen SpeciesSilicon DioxideActinslauric acidLauric AcidsReactive Oxygen SpeciesSilicon Dioxidebreast cancerhyperthermal therapylauric acidnanoencapsulation

Identifiers

PMID31141939
PMCPMC6600235
OpenAlexW2946929964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.