ArticlePloS one2019
Left ventricular mass is underestimated in overweight children because of incorrect body size variable chosen for normalization.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Echocardiographic assessment of cardiac growth in children with structurally normal hearts.American heart journal plus : cardiology research and practice · 2026Article
- Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study.European journal of applied physiology · 2023Article
- Cardiac Magnetic Resonance Derived Left Ventricular Eccentricity Index and Right Ventricular Mass Measurements Predict Outcome in Children with Pulmonary Arterial Hypertension.Children (Basel, Switzerland) · 2023Article
- Height Versus Body Surface Area to Normalize Cardiovascular Measurements in Children Using the Pediatric Heart Network Echocardiographic Z-Score Database.Pediatric cardiology · 2021Article
- Left ventricular mass normalization in child and adolescent athletes must account for sex differences.PloS one · 2020Article
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5 authors.
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Abstract
backgroundLeft ventricular mass normalization for body size is recommended, but a question remains: what is the best body size variable for this normalization-body surface area, height or lean body mass computed based on a predictive equation? Since body surface area and computed lean body mass are derivatives of body mass, normalizing for them may result in underestimation of left ventricular mass in overweight children. The aim of this study is to indicate which of the body size variables normalize left ventricular mass without underestimating it in overweight children.
methodsLeft ventricular mass assessed by echocardiography, height and body mass were collected for 464 healthy boys, 5-18 years old. Lean body mass and body surface area were calculated. Left ventricular mass z-scores computed based on reference data, developed for height, body surface area and lean body mass, were compared between overweight and non-overweight children. The next step was a comparison of paired samples of expected left ventricular mass, estimated for each normalizing variable based on two allometric equations-the first developed for overweight children, the second for children of normal body mass.
resultsThe mean of left ventricular mass z-scores is higher in overweight children compared to non-overweight children for normative data based on height (0.36 vs. 0.00) and lower for normative data based on body surface area (-0.64 vs. 0.00). Left ventricular mass estimated normalizing for height, based on the equation for overweight children, is higher in overweight children (128.12 vs. 118.40); however, masses estimated normalizing for body surface area and lean body mass, based on equations for overweight children, are lower in overweight children (109.71 vs. 122.08 and 118.46 vs. 120.56, respectively).
conclusionNormalization for body surface area and for computed lean body mass, but not for height, underestimates left ventricular mass in overweight children.
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