Evidence map›Paper›PMID 31141683›Full record

ArticleCell reports2019

Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism.

Maria T Lazaro, Jiannis Taxidis, Tristan Shuman, Iris Bachmutsky, Taruna Ikrar, Rommel Santos, G Mark Marcello, Apoorva Mylavarapu, Swasty Chandra, Allison Foreman and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Pooled it
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  6. Autism associatedbioRxiv : the preprint server for biology · 2026
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  20. Autism-associatedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 3 countries.

Maria T LazaroInterdepartmental Program for Neuroscience, UCLA, Los Angeles, CA, USA; Center for Neurobehavioral Genetics, Semel Institute, UCLA, Los Angeles, CA, USA; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Jiannis TaxidisDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA, USA.
Tristan ShumanDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Iris BachmutskyDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Taruna IkrarDepartment of Anatomy and Neurobiology, UC Irvine, Irvine, CA, USA.
Rommel SantosDepartment of Anatomy and Neurobiology, UC Irvine, Irvine, CA, USA.
G Mark MarcelloDepartment of Anatomy and Histology, University of Veterinary Medicine, Budapest, Hungary.
Apoorva MylavarapuDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Swasty ChandraDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Allison ForemanDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Rachna GoliDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Duy TranDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Nikhil SharmaDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Michelle AzhdamDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Hongmei DongDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Katrina Y ChoeCenter for Neurobehavioral Genetics, Semel Institute, UCLA, Los Angeles, CA, USA.
Olga PeñagarikanoDepartment of Pharmacology, School of Medicine, University of the Basque Country (UPV/EHU), Vizcaya, Spain; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Madrid, Spain.
Sotiris C MasmanidisIntegrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA, USA.
Bence RáczDepartment of Anatomy and Histology, University of Veterinary Medicine, Budapest, Hungary.
Xiangmin XuDepartment of Anatomy and Neurobiology, UC Irvine, Irvine, CA, USA.
Daniel H GeschwindCenter for Neurobehavioral Genetics, Semel Institute, UCLA, Los Angeles, CA, USA; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Center for Autism Research and Treatment, Semel Institute, UCLA, Los Angeles, CA, USA; Intellectual Development and Disabilities Research Center, UCLA, Los Angeles, CA, USA. Electronic address: dhg@mednet.ucla.edu.
Peyman GolshaniDepartment of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA, USA; Intellectual Development and Disabilities Research Center, UCLA, Los Angeles, CA, USA; West Los Angeles VA Medical Center, Los Angeles, CA. Electronic address: pgolshani@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of California, Irvine · USUniversity of Veterinary Medicine · HUCenter for Autism and Related Disorders · USCentro de Investigación Biomédica en Red de Salud Mental · ES

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2007 to 2021
$32.0M
UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2016 to 2020
$6.5M
1/2 Cross modal integration of molecular and physiological networks in ASDU01MH115746 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H, MEHTA, MAYANK R · 2017 to 2021
$5.3M
Building and sharing next generation open-source, wireless, multichannel miniaturized microsopes for imaging activity in freely behaving miceU01NS094286 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, KHAKH, BALJIT · 2015 to 2017
$2.7M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
Inhibitory neuron circuit organization and function in prefrontal cortex.R01MH105427 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLSHANI, PEYMAN, XU, XIANGMIN · 2015 to 2019
$2.3M
Neural circuit organization and function of the bed nucleus of the stria terminalisR01MH113026 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2017 to 2021
$2.2M
Optogenetic treatment of social behavior in autismR01MH101198 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN · 2013 to 2017
$2.0M
Cerebellar contributions to movement explored with patterned optical manipulationR01NS090930 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN · 2014 to 2018
$1.6M
Systems-level electrophysiology for addiction and reward researchR01DA034178 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MASMANIDIS, SOTIRIS · 2012 to 2016
$1.5M
NICHD NIH HHS P50 HD055784NICHD NIH HHS U54 HD087101NIDA NIH HHS R01 DA034178NIGMS NIH HHS R25 GM055052NIMH NIH HHS R01 MH101198NIMH NIH HHS R01 MH105427NIMH NIH HHS R01 MH113026NIMH NIH HHS T32 MH073526NIMH NIH HHS U01 MH115746NINDS NIH HHS R01 NS090930NINDS NIH HHS U01 NS094286
6 · The paper itself

Abstract

Loss-of-function mutations in CNTNAP2 cause a syndromic form of autism spectrum disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice. However, the functional effects of these mutations at cellular and circuit levels remain elusive. Using laser-scanning photostimulation, whole-cell recordings, and electron microscopy, we found a dramatic decrease in excitatory and inhibitory synaptic inputs onto L2/3 pyramidal neurons of the medial prefrontal cortex (mPFC) of Cntnap2 knockout (KO) mice, concurrent with reduced spines and synapses, despite normal dendritic complexity and intrinsic excitability. Moreover, recording of mPFC local field potentials (LFPs) and unit spiking in vivo revealed increased activity in inhibitory neurons, reduced phase-locking to delta and theta oscillations, and delayed phase preference during locomotion. Excitatory neurons showed similar phase modulation changes at delta frequencies. Finally, pairwise correlations increased during immobility in KO mice. Thus, reduced synaptic inputs can yield perturbed temporal coordination of neuronal firing in cortical ensembles.

Indexed as

AnimalsAutistic DisorderDendritesDisease Models, AnimalExcitatory Postsynaptic PotentialsFemaleMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsPrefrontal CortexPyramidal CellsSynapsesCNTNAP2 protein, mouseMembrane ProteinsNerve Tissue Proteinsbiomarkerbrain stateconnectivitydeltaEEGfunctionalinhibitionoscillationphase-lockingtheta

Identifiers

PMID31141683
PMCPMC6553483
OpenAlexW2952701408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.