Evidence map›Paper›PMID 31141681›Full record

ArticleCell reports2019

Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation.

Joo-Young Park, Devon T DiPalma, Juntae Kwon, Juliet Fink, Jung-Hyun Park

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Markers and makers of NKT17 cells.Experimental & molecular medicine · 2023
    Review
  13. Article
  14. Article
  15. Virtual Memory CD8Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Joo-Young ParkExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1360, USA; Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, 101 Daehakno, Jongno-gu, Seoul 03080, South Korea.
Devon T DiPalmaExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1360, USA.
Juntae KwonExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1360, USA.
Juliet FinkExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1360, USA.
Jung-Hyun ParkExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1360, USA. Electronic address: parkhy@mail.nih.gov.
National Cancer Institute · USSeoul National University Hospital · KR

Funding

Post-Transcriptional Regulation of Interleukin-7 Receptor ExpressionZIABC011214 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PARK, JUNG-HYUN · 2009 to 2025
$15.9M
Immune Regulatory Roles of Suppressor Of Cytokine Signaling (SOCS) MoleculesZIABC011215 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PARK, JUNG-HYUN · 2009 to 2025
$6.9M
Intramural NIH HHS ZIA BC011214Intramural NIH HHS ZIA BC011215
6 · The paper itself

Abstract

Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus. Here, we report that not only PLZF expression itself but also the relative abundance of PLZF proteins plays critical roles in iNKT cell development. Utilizing a Zbtb16 hypomorphic allele, PLZF

Indexed as

Cell DifferentiationCell LineageAnimalsCD4-Positive T-LymphocytesCells, CulturedFemaleMaleMiceMice, Inbred BALB CMice, Inbred C57BLNatural Killer T-CellsPromyelocytic Leukemia Zinc Finger ProteinThymocytesPromyelocytic Leukemia Zinc Finger ProteinZbtb16 protein, mouseIFN-γIL-4iNKT cellsthymustranscription factor

Identifiers

PMID31141681
PMCPMC8274958
OpenAlexW2947304419

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.