Trial reportBehavioral medicine (Washington, D.C.)
Benefits of Yoga on IL-6: Findings from a Randomized Controlled Trial of Yoga for Depression.
Trial report in Behavioral medicine (Washington, D.C.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06091527 (Treating Major Depression With Yoga Mono-therapy), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treating Major Depression With Yoga Mono-therapy: 12-Week Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Disentangling the biological mechanisms underlying the effects of physical exercise in major depressive disorder: a comprehensive systematic review of randomized controlled trials.Psychological medicine · 2025Pooled it
- Mind-body therapies for pro-inflammatory cytokines in patients with depression: findings from a systematic review of randomized controlled trials.Frontiers in immunology · 2025Pooled it
- Effectiveness of yoga for major depressive disorder: A systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Serum and gene expression profile of cytokines following combination of yoga training and vitamin D supplementation in breast cancer survivors: a randomized controlled trial.BMC women's health · 2022Trial
- Non-participation Rate and Recruitment Barriers in Offering Yoga Intervention for Depression: A Scoping Review.Annals of neurosciences · 2026Review
- Optimal doses of mind-body exercise on neuroinflammation in individuals with neuropsychiatric disorders: A systematic review and dose-response meta-analysis.Brain, behavior, & immunity - health · 2026Article
- Effects of cyclic yoga on selected metabolic and hepatic parameters in diabetic women with fatty liver diseases: A clinical trial.Journal of clinical & translational endocrinology · 2026Article
- Effects of Mind-Body Interventions on Immune and Neuroendocrine Functions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2025Review
- The Effects of Yoga on the Mental Health of Individuals With Autoimmune Disorders: A Scoping Review.Cureus · 2025Review
- The Mediating Effects of Self-Acceptance and Self-Evaluation on Mindfulness and Benefit -Finding in a Sample of Chinese Systemic Lupus Erythematous Patients.Patient preference and adherence · 2025Article
- What can the psychoneuroimmunology of yoga teach us about depression's psychopathology?Brain, behavior, & immunity - health · 2024Article
- Are There Biological Correlates of Response to Yoga-Based Interventions in Depression? A Critical Scoping Review.Brain sciences · 2024Article
- Effectiveness of Yoga in Modulating Markers of Immunity and Inflammation: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Review
- Utilization of Mind-Body Intervention for Integrative Health Care of COVID-19 Patients and Survivors.International journal of environmental research and public health · 2022Review
- Yoga, immunity and COVID-19: A scoping review.Journal of family medicine and primary care · 2022Article
- The role of yoga in inflammatory markers.Brain, behavior, & immunity - health · 2022Article
- Yoga, Meditation, Breathing Exercises, and Inflammatory Biomarkers with Possible Implications in COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Role of Interleukin-6 in Depressive Disorder.International journal of molecular sciences · 2020Review
- Inflammation and Oxidative Stress in Male Infertility: A Narrative Review.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The present research sought to examine whether hatha yoga, implemented as an adjunctive intervention for major depression, influences markers of inflammation. A subset of 84 participants who were enrolled in a randomized controlled trial (RCT) of hatha yoga vs. health education control provided blood samples at baseline (pre-treatment) and at 3-(during treatment) and 10-week (end of treatment) follow-up visits. To be eligible for the RCT, participants met criteria for a current or recent (past two years) major depressive episode, had current elevated depression symptoms, and current antidepressant medication use. Venous blood was drawn between 2 and 6 pm and following at least one hour of fasting, and inflammatory markers (IL-6, CRP, and TNF-α) were assayed. Effects of participation in yoga relative to health education on inflammatory markers over time were examined with latent growth analyses. We observed a significant reduction in IL-6 concentrations in the yoga treatment group relative to the health education control group as demonstrated by a negative interaction between treatment group and slope of IL-6. TNF-α and CRP did not evidence significant interactions of treatment group by mean slope or intercept. In addition to the benefits of hatha yoga as an adjunctive intervention for individuals who have shown inadequate response to antidepressant medications, our findings point to possible benefits of yoga on IL-6 in depressed populations. Further research is needed to explore the effects of hatha yoga on immune function over time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.