Evidence map›Paper›PMID 31141462›Full record

ArticleMolecular biology of the cell2019

Tau tubulin kinase is required for spermatogenesis and development of motile cilia in planarian flatworms.

Robert Alan Magley, Labib Rouhana

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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  5. Exploring the potential ofCurrent research in toxicology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert Alan MagleyDepartment of Biological Sciences, Wright State University, Dayton, OH 45435.
Labib RouhanaDepartment of Biological Sciences, Wright State University, Dayton, OH 45435.
Wright State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Discovery of germline genes and regulatory networks in planariansR15HD082754 · NICHD · WRIGHT STATE UNIVERSITY · PI ROUHANA, LABIB · 2014 to 2024
$1.3M
NCI NIH HHS P30 CA016058NICHD NIH HHS R15 HD082754
6 · The paper itself

Abstract

Cilia are microtubule-based structures that protrude from the apical surface of cells to mediate motility, transport, intracellular signaling, and environmental sensing. Tau tubulin kinases (TTBKs) destabilize microtubules by phosphorylating microtubule-associated proteins (MAPs) of the MAP2/Tau family, but also contribute to the assembly of primary cilia during embryogenesis. Expression of TTBKs is enriched in testicular tissue, but their relevance to reproductive processes is unknown. We identified six TTBK homologues in the genome of the planarian

Indexed as

AnimalsCiliaMaleMicrotubule-Associated ProteinsPhosphorylationPlanariansProtein Serine-Threonine KinasesRegenerationRNA InterferenceSignal TransductionSpermatogenesisTubulinMicrotubule-Associated ProteinsProtein Serine-Threonine Kinasestau-tubulin kinaseTubulin

Identifiers

PMID31141462
PMCPMC6743461
OpenAlexW2947300110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.