Evidence map›Paper›PMID 31141401›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Accumulation of uremic solutes in the cerebrospinal fluid in experimental acute renal failure.

Robert DeWolfe Mair, Huy Nguyen, Ting-Ting Huang, Natalie S Plummer, Tammy L Sirich, Timothy W Meyer

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Robert DeWolfe MairDivision of Nephrology, Stanford University , Stanford, California.ORCID 0000-0001-5860-7276
Huy NguyenDepartment of Neurology and Neurological Sciences, Stanford University , Stanford, California.
Ting-Ting HuangDepartment of Neurology and Neurological Sciences, Stanford University , Stanford, California.
Natalie S PlummerDepartment of Medicine, Veterans Affair Palo Alto Health Care System, Palo Alto, California.
Tammy L SirichDivision of Nephrology, Stanford University , Stanford, California.
Timothy W MeyerDivision of Nephrology, Stanford University , Stanford, California.
VA Palo Alto Health Care System · USGeriatric Research Education and Clinical Center · USStanford University · US

Funding

Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced MetabolitesR01DK101674 · NIDDK · STANFORD UNIVERSITY · PI FISCHBACH, MICHAEL ANDREW, MEYER, TIMOTHY W · 2014 to 2024
$6.5M
The Colon Microbiome in Dialysis PatientsF32DK111166 · NIDDK · STANFORD UNIVERSITY · PI MAIR, ROBERT DEWOLFE · 2016 to 2018
$190k
CSRD VA IK2 CX001036NIDDK NIH HHS F32 DK111166NIDDK NIH HHS R01 DK101674
6 · The paper itself

Abstract

The accumulation of uremic solutes in kidney failure may impair mental function. The present study profiled the accumulation of uremic solutes in the cerebrospinal fluid (CSF) in acute renal failure. CSF and plasma ultrafiltrate were obtained from rats at 48 h after sham operation (control;

Indexed as

Acute Kidney InjuryAnimalsBiomarkersBlood-Brain BarrierBrain DiseasesChromatography, High Pressure LiquidDisease Models, AnimalDisease ProgressionKidneyMaleMetabolomicsNephrectomyRats, Sprague-DawleySpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryUremiaBiomarkersbraincerebrospinal fluidend-stage renal diseaseuremic encephalopathyuremic toxins

Identifiers

PMID31141401
PMCPMC6732458
OpenAlexW2947670524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.