ArticleeLife2019
Club cells form lung adenocarcinomas and maintain the alveoli of adult mice.
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Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
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Corrections and comments
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Authors and funding
23 authors at 5 institutions in 2 countries.
Magda SpellaLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.ORCID 0000-0003-2505-7778
Ioannis LilisLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Mario Aa PepeComprehensive Pneumology Center (CPC), Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University, Helmholtz Center Munich, The German Center for Lung Research (DZL), Munich, Germany.
Yuanyuan ChenDivision of Molecular Thoracic Oncology, Translational Lung Research Center (TLRC), German Cancer Research Center (DKFZ), The German Center for Lung Research (DZL), Heidelberg, Germany.
Maria ArmakaInstitute of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
Anne-Sophie LamortComprehensive Pneumology Center (CPC), Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University, Helmholtz Center Munich, The German Center for Lung Research (DZL), Munich, Germany.
Dimitra E ZazaraLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Fani RoumeliotiInstitute of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
Malamati VrekaLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Nikolaos I KanellakisLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Darcy E WagnerComprehensive Pneumology Center (CPC), Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University, Helmholtz Center Munich, The German Center for Lung Research (DZL), Munich, Germany.
Anastasios D GiannouLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Vasileios ArmenisLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Kristina Am ArendtComprehensive Pneumology Center (CPC), Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University, Helmholtz Center Munich, The German Center for Lung Research (DZL), Munich, Germany.
Laura V KlotzComprehensive Pneumology Center (CPC), Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University, Helmholtz Center Munich, The German Center for Lung Research (DZL), Munich, Germany.
Dimitrios ToumpanakisFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Vassiliki KaravanaFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Spyros G ZakynthinosFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Ioanna GiopanouLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Antonia MaraziotiLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.
Vassilis AidinisInstitute of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Vari, Greece.
Rocio Sotillo *Division of Molecular Thoracic Oncology, Translational Lung Research Center (TLRC), German Cancer Research Center (DKFZ), The German Center for Lung Research (DZL), Heidelberg, Germany.ORCID 0000-0002-0855-7917
Georgios T Stathopoulos *Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Greece.ORCID 0000-0002-9215-6461
University of Patras · GRGerman Center for Lung Research · DEAlexander Fleming Biomedical Sciences Research Center · GRNational and Kapodistrian University of Athens · GRGerman Cancer Research Center · DE
Funding
H2020 European Research Council 260524H2020 European Research Council 281614H2020 European Research Council 679345Hellenic State Scholarship Foundation Post-doctoral Research FellowshipHellenic State Scholarships Foundation Post-doctoral Research FellowshipHellenic Thoracic Society PhD FellowshipHoward Hughes Medical Institute International Research Scholars Award
Abstract
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epithelial turnover observed with chronic lung diseases are unknown. To address this, we combined mouse models of genetic labeling and ablation of airway (club) and alveolar cells with exposure to environmental noxious and carcinogenic agents. Club cells are shown to survive
Indexed as
Environmental ExposureAdenocarcinoma of LungAnimalsCarcinogensCell ProliferationCell SurvivalDisease Models, AnimalEpithelial CellsMicePulmonary AlveoliRespiratory MucosaTobacco SmokingCarcinogensairway transcriptomecancer biologycell biologychemical carcinogenesishumanlung adenocarcinomamouseurethane
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.