Evidence map›Paper›PMID 31140698›Full record

SynthesisOral diseases2019

World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies.

Alessandro Villa, Antonio Celentano, Ingrid Glurich, Wenche S Borgnakke, Siri Beier Jensen, Douglas E Peterson, Konstantina Delli, David Ojeda, Arjan Vissink, Camile S Farah

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oral diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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  11. [Progress in clinicopathological diagnosis of oral potentially malignant disorders].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Alessandro VillaDivision of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts.ORCID https://orcid.org/0000-0002-1966-6000
Antonio CelentanoMelbourne Dental School, The University of Melbourne, Melbourne, Victoria, Australia.
Ingrid GlurichCenter for Oral and Systemic Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin.
Wenche S BorgnakkeDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan.
Siri Beier JensenDepartment of Dentistry and Oral Health, Faculty of Health, Aarhus University, Aarhus, Denmark.
Douglas E PetersonOral Medicine Section, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, UConn Health, Farmington, Connecticut.ORCID https://orcid.org/0000-0002-2665-4964
Konstantina DelliDepartment of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-3115-3977
David OjedaDepartment of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio, San Antonio, Texas.
Arjan VissinkDepartment of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-2581-4361
Camile S FarahAustralian Centre for Oral Oncology Research & Education, Perth, Westren Australia, Australia.ORCID https://orcid.org/0000-0002-1642-6204
University Medical Center Groningen · NLAarhus University · DKBrigham and Women's Hospital · USMarshfield Clinic · USThe University of Melbourne · AUThe University of Texas Health Science Center at San Antonio · USUConn Health · USUniversity of Michigan · US

Funding

Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
Seventh World Workshop on Oral MedicineR13DE027613 · NIDCR · CAROLINAS MEDICAL CENTER · PI LOCKHART, PETER B · 2018 to 2018
$15k
AFYXAmerican Academy of Oral MedicineColgate-PalmoliveEuropean Association of Oral MedicineHenry Schein Cares FoundationNIDCR NIH HHS R13 DE027613NIDDK NIH HHS P30 DK092926Oral DiseasesThe British Society for Oral MedicineThe National Institute of Dental and Craniofacial ResearchThe World Dental Education FoundationUnileverXerostom
6 · The paper itself

Abstract

objectiveTo identify the prognostic biomarker candidates for stratification and long-term surveillance of oral leukoplakia progressing to cancer via a systematic literature review. MATERIALS AND

methodsSystematic searches with no date restrictions were conducted on March 29, 2018, targeting the databases PubMed (Ovid), EMBASE (Ovid), EBM (Ovid), and Web of Science (ISI). Bias was assessed using the Quality in Prognosis Studies tool. Biomarkers were stratified based on hallmarks of cancer.

resultsInclusion criteria were met by 25 of 3,415 studies. A range of biomarkers were evaluated experimentally for risk stratification, prognosis, and surveillance of oral leukoplakia in tissue, blood, and saliva. However, the studies were highly heterogeneous and require further validation. Biomarkers reported in these studies included inflammatory or oxidative markers, growth factors, ion channels, genetic and cellular regulatory factors, and epigenetic biomarkers. Studies tended to include small sample sizes, under-reported or variably reported histopathological data, did not address potential confounding, reported limited/variable follow-up data, or lacked a control group. Inclusion of subsets from chemoprevention trials may have introduced bias regarding reported malignant transformation rates and accuracy of prognostic biomarkers.

conclusionsThis review identified insufficient longitudinal evidence to support validated prognostic biomarkers for oral leukoplakia. Further studies are needed to identify molecular targets with the potential to mitigate risk of malignant transformation.

Indexed as

BiomarkersCell Transformation, NeoplasticCongresses as TopicHumansLeukoplakia, OralMouth MucosaMouth NeoplasmsPredictive Value of TestsPrognosisRisk FactorsBiomarkersbiomarkerscancer progressionleukoplakianeoplastic cell transformationprognosistumor

Identifiers

PMID31140698
PMCPMC6544170
OpenAlexW2947841111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.