SynthesisInternational dental journal2019
Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review.
Synthesis in International dental journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Masticatory Dysfunction and Hippocampal Volume in Ageing Adults: An MRI-Based Scoping Review.Journal of oral rehabilitation · 2026Article
- Reduced Posterior Occlusal Contacts Are Associated With an Increased Risk of Stroke: A Retrospective Study Based on a Japanese Claims Database.Journal of the American Heart Association · 2026Article
- Physical disorders, ADLs, cognition, and depression in nursing home residents: a parallel mediation analysis.BMC geriatrics · 2026Article
- Article
- Association of Oral Hypofunction with Reduced Hand Dexterity in Community-Dwelling Older Adults: A Cross-Sectional Study.Clinical interventions in aging · 2026Article
- Development and External Validation of an Explainable Machine Learning Model to Identify Positive Dysphagia Screening Results in People with Dementia: A Multicenter Cross-Sectional Study.Clinical interventions in aging · 2026Article
- The Neural Correlates of Chewing Gum-A Neuroimaging Review of Its Effects on Brain Activity.Brain sciences · 2025Review
- The Association Between Tooth Loss and Hearing Impairment: Partial Compensation with Dental Implants.The journal of international advanced otology · 2025Article
- The Relationship between Removable Dental Prostheses and Brain Activity in Elderly Individuals: Systematic Review.Rambam Maimonides medical journal · 2025Review
- Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia.Journal of clinical periodontology · 2025Article
- Dietary Counseling: An Option to Malnutrition and Masticatory Deficiency in Patients with Total Protheses? A Scoping Review.Nutrients · 2024Article
- Article
- Risk factors of cognitive impairment: Impact of decline in oral function.The Japanese dental science review · 2023Review
- Impact of Denture Prostheses on Cognitive Functioning in Completely Edentulous Patients: A Pilot Study.Cureus · 2023Article
- Assessment and Improvement of Masticatory Performance in Frail Older People: A Narrative Review.Journal of clinical medicine · 2023Review
- Association between Dietary Hardness and Cognitive Dysfunction among Japanese Men in Their 60s: A Cross-Sectional Study.Nutrients · 2023Article
- The Masticatory Activity Interference in Quantitative Estimation of CA1, CA3 and Dentate Gyrus Hippocampal Astrocytes of Aged Murine Models and under Environmental Stimulation.International journal of molecular sciences · 2023Article
- Assessment of Oral Health in Long-Term Enteral and Parenteral Nutrition Patients: Significant Aspects of Nursing Care.International journal of environmental research and public health · 2023Review
- Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms.Current osteoporosis reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA relationship between masticatory function and cognition has been reported. It is proposed that mastication changes the blood flow stimulating the perfusion/oxygenation of the brain. This literature review analysed the relation between mastication as a protective factor of the cognitive decline and the changes produced at brain level in adults associated with the brain blood flow. MATERIALS AND
methodsA systematic review was performed according to the 'Preferred Reporting Items for Systematic Reviews and Meta-Analyses' (PRISMA) criteria in PubMed/MEDLINE, Web of Science, Scopus and Embase. Primary studies were included with no limit on the publication date, conducted on humans, and that established a relation between mastication, brain blood flow and cognitive functions in adult patients.
resultsNine clinical descriptive studies were selected and qualitatively analysed. The collected data suggest the greatest brain areas activated during mastication were the frontotemporal cortex, the caudate nucleus and the thalamus, revealing a positive correlation between chewing intensity and perfusion of the principal trigeminal nucleus. The increase in cerebral blood flow was measured by a local vasodilator effect resulting in increased neuronal metabolism in the region linked to learning and memory. In addition, partially edentulous participants had a marked prefrontal deactivation when they chewed without a prosthesis and presented a decrease in masticatory activity.
conclusionMasticatory function may act as a protective factor in those patients with cognition impairment and neurodegenerative diseases, suggesting some mechanisms among which is the increase of cerebral blood flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.