Evidence map›Paper›PMID 31140423›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019

[Expression of KCNA2 in the dorsal root ganglia of rats with osteoarthritis pain induced by monoiodoacetate].

Qihong Zhao, Qiyou Wang, Jie Xu, Jiafeng Wang, Xiaoming Deng

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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qihong ZhaoDepartment of Anesthesiology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Qiyou WangDepartment of Orthopedics, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Jie XuDepartment of Human Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Jiafeng WangDepartment of Anesthesiology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Xiaoming DengDepartment of Anesthesiology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the changes in the expression of voltage-gated potassium channel subunit KCNA2 in the dorsal root ganglion (DRG) neurons of rats with osteoarthritis (OA) pain induced by sodium monoiodoacetate and explore the mechanism.

methodsA total of 156 adult male Sprague-Dawley rats were randomly divided into blank control group, saline group and intra-articular monoiodoacetate injection-induced OA group. The paw withdrawal mechanical threshold (PWMT) was measured before and at 1, 2, 4, and 6 weeks after monoiodoacetate injection. At 4 weeks after the injection, the pathological changes in the knee joints were analyzed using HE staining and Safranin O-Fast Green staining, and the expression of activating transcription factor 3 (ATF-3) and inducible nitric oxide synthase (iNOS) in the DRG neurons were detected by immunofluorescence staining. The expression of

resultsThe PWMT of the rats in OA group was significantly decreased at 2, 4, and 6 weeks after the injection as compared with the baseline (

conclusionsThe expression of KCNA2 is decreased in the DRG neurons of rats with OA pain likely as a result of enhanced methylation of

Indexed as

Ganglia, SpinalOsteoarthritisPainAnimalsDisease Models, AnimalKnee JointKv1.2 Potassium ChannelMalePromoter Regions, GeneticRatsRats, Sprague-DawleyKcna2 protein, ratKv1.2 Potassium Channeldorsal root ganglionosteoarthritispainvoltage-gated potassium channel

Identifiers

PMID31140423
PMCPMC6743928
OpenAlexW3025342719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.