Evidence map›Paper›PMID 31140110›Full record

ArticleMolecular imaging and biology2020

Semiquantitative Parameters in PSMA-Targeted PET Imaging with [

Rudolf A Werner, Ralph A Bundschuh, Lena Bundschuh, Constantin Lapa, Yafu Yin, Mehrbod S Javadi, Andreas K Buck, Takahiro Higuchi, Kenneth J Pienta, Martin G Pomper and 3 more

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  17. Tumor Sink Effect inJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
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  20. Appropriate Use Criteria for Prostate-Specific Membrane Antigen PET Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Rudolf A WernerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ralph A BundschuhDepartment of Nuclear Medicine, University Medical Center Bonn, Bonn, Germany.
Lena BundschuhDepartment of Nuclear Medicine, University Medical Center Bonn, Bonn, Germany.
Constantin LapaDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Yafu YinThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mehrbod S JavadiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Takahiro HiguchiDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Kenneth J PientaThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Martin G PomperThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Martin A LodgeThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael A GorinThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steven P RoweThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. srowe8@jhmi.edu.
Johns Hopkins University · USUniversitätsklinikum Würzburg · DEChina Medical University · CNMedizinische Hochschule Hannover · DE

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
Small Molecule PSMA-Targeted Alpha TherapyR01CA184228 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G, ZALUTSKY, MICHAEL ROD · 2014 to 2023
$3.6M
PSMA Directed Imaging of Prostate Cancer Focus on Androgen Receptor DynamicsU01CA183031 · NCI · JOHNS HOPKINS UNIVERSITY · PI DEWEESE, THEODORE L, POMPER, MARTIN G · 2015 to 2017
$1.2M
NCI NIH HHS R01 CA134675NCI NIH HHS R01 CA184228NCI NIH HHS U01 CA183031NIBIB NIH HHS P41 EB024495
6 · The paper itself

Abstract

purposeIn this study, we aimed to quantitatively investigate the biodistribution of [ PROCEDURES: Fifty patients who had been imaged with [

resultsThere was no significant correlation between TV with the vast majority of the investigated organs (lacrimal glands, parotid glands, submandibular glands, spleen, and liver). Only the kidney showed significant correlation: With an isocontour threshold at 50 %, left kidney uptake parameters correlated significantly with TV (SUV

conclusionsOnly a minimal sink effect with high tumor burden in patients imaged with [

Indexed as

Tumor BurdenAgedAntigens, SurfaceFluorine RadioisotopesGlutamate Carboxypeptidase IIHumansLysineMaleOrgans at RiskPositron-Emission TomographyProstatic NeoplasmsRadiometryRadiopharmaceuticalsRetrospective StudiesTissue DistributionUrea2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acidAntigens, SurfaceFluorine-18Fluorine RadioisotopesFOLH1 protein, humanGlutamate Carboxypeptidase IILysineRadiopharmaceuticalsUrea[18F]DCFPyLBiodistributionPositron emission tomographyProstate-specific membrane antigenPSMA

Identifiers

PMID31140110
PMCPMC7771227
OpenAlexW2947342082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.