ArticleIn vitro cellular & developmental biology. Animal2019
Identification and functional characterization of lactadherin, an agglutinating glycoprotein from the chordate Styela clava.
Article in In vitro cellular & developmental biology. Animal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- The active roles ofFrontiers in veterinary science · 2025Article
- Spatially resolved single-cell atlas of ascidian endostyle provides insight into the origin of vertebrate pharyngeal organs.Science advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Lactadherin is an extracellular matrix glycoprotein with stimulating agglutination ability that plays crucial roles in animal immunology. In the present study, a novel lactadherin, Sc-lactadherin, was identified from the marine invertebrate chordate, Styela clava. Its full-length cDNA consisted of 579 bps, encoding 193 amino acids with a coagulation FA58C domain. Recombinant Sc-lactadherin via a prokaryotic expression system showed strong hemocyte fusion activity. Therefore, we further examined its effects on cell behaviors using human umbilical vein endothelial cells (HUVECs) and human cervical cancer (HeLa) cells. Recombinant Sc-lactadherin significantly increased the proliferation rate of HUVECs and HeLa cells and improved the cell migration rate of HUVECs. These results demonstrated that the lactadherin identified from the marine ascidian displayed the agglutinating activity. Functional characterization of the recombinant protein showed that it promoted cell proliferation and migration, indicating the potential roles of Sc-lactadherin in immunology and organogenesis in marine ascidians.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.