Evidence map›Paper›PMID 31140036›Full record

ReviewInflammopharmacology2019

Curcumin: a modulator of inflammatory signaling pathways in the immune system.

Kolsoum Rezaie Kahkhaie, Ali Mirhosseini, Ali Aliabadi, Asadollah Mohammadi, Mohammad Javad Mousavi, Saeed Mohammadian Haftcheshmeh, Thozhukat Sathyapalan, Amirhossein Sahebkar

Erratum issuedOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 8 pooled it
4.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 8 syntheses or guidelines pooled it, 225 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Kolsoum Rezaie KahkhaieDepartment of Medical Biochemistry, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Ali MirhosseiniImmunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ali AliabadiDepartment of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Asadollah MohammadiCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Mohammad Javad MousaviDepartment of Immunology and Allergy, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Saeed Mohammadian HaftcheshmehDepartment of Medical Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 91766-99199, Iran. Mohammadianhs941@mums.ac.ir.
Thozhukat SathyapalanDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, HU3 2JZ, UK.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.ORCID http://orcid.org/0000-0002-8656-1444
Mashhad University of Medical Sciences · IRBushehr University of Medical Sciences · IRKurdistan University of Medical Sciences · IRUniversity of Hull · GBZabol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1.

Indexed as

AnimalsCurcuminHumansImmune SystemInflammationSignal TransductionCurcuminCurcuminInflammationInflammatory diseasesInflammatory signaling pathway

Identifiers

PMID31140036
OpenAlexW2947524960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.