ArticleEuropean radiology2019
Synthetic T2 mapping is correlated with time from stroke onset: a future tool in wake-up stroke management?
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety of intravenous thrombolysis in stroke of unknown time of onset: A systematic review and meta-analysis.Journal of thrombosis and thrombolysis · 2021Pooled it
- Carrier-Free Rapamycin-Loaded Nanoparticles with MRI and Near-Infrared Fluorescence Bimodal Imaging for Precise Diagnosis and Synergistic Therapy of Ischemic Stroke.International journal of nanomedicine · 2026Article
- Characterizing Protein Concentration in Cerebrospinal Fluid with TMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Synthetic MR: Clinical applications in neuroradiology.Neuroradiology · 2025Review
- Assessment of accuracy and repeatability of quantitative parameter mapping in MRI.Radiological physics and technology · 2024Article
- Synthetic MRI and amide proton transfer-weighted MRI for differentiating between benign and malignant sinonasal lesions.European radiology · 2024Article
- Evaluating T1, T2 Relaxation, and Proton Density in Normal Brain Using Synthetic MRI with Fast Imaging Protocol.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Article
- Novel advanced imaging techniques for cerebral oedema.Frontiers in neurology · 2024Review
- The effect of cerebral blood perfusion on the correlation between cerebral stroke onset time and synthetic T2 mapping: a pilot study.Quantitative imaging in medicine and surgery · 2023Article
- Focal epilepsy without overt epileptogenic lesions: no evidence of microstructural brain tissue damage in multi-parametric quantitative MRI.Frontiers in neurology · 2023Article
- An Intermodal Correlation Study among Imaging, Histology, Procedural and Clinical Parameters in Cerebral Thrombi Retrieved from Anterior Circulation Ischemic Stroke Patients.Journal of clinical medicine · 2022Article
- Synthetic MRI for stroke: a qualitative and quantitative pilot study.Scientific reports · 2022Article
- The effect of scan parameters on T1, T2 relaxation times measured with multi-dynamic multi-echo sequence: a phantom study.Physical and engineering sciences in medicine · 2022Article
- Application of MAGnetic resonance imaging compilation in acute ischemic stroke.World journal of clinical cases · 2021Article
- Wake-up stroke: imaging-based diagnosis and recanalization therapy.Journal of neurology · 2021Review
- Quantitative Analysis of Synthetic Magnetic Resonance Imaging in Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Multiparametric Quantitative MRI in Neurological Diseases.Frontiers in neurology · 2021Review
- A Comparison of TJournal of central nervous system disease · 2020Article
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Authors and funding
6 authors.
Funding
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Abstract
objectivesFLAIR-DWI mismatch is an effective method to select eligible wake-up stroke (WUS) patients for intravenous thrombolysis, but shows limitations in the case of subtle FLAIR hyperintensities. T2 mapping is a quantitative method, directly generated from synthetic MRI, which provides T2 relaxation times. We aimed to assess the correlation between T2 values and onset time in acute stroke patients.
methodsWe prospectively included stroke patients in the 4.5-h window undergoing brain MRI including MAGnetic resonance Image Compilation (MAGiC) from March to October 2017. T2 relaxation times and FLAIR signal intensities were measured in ischemic and contralateral nonischemic regions to calculate FLAIR signal intensity ratio (rSI), difference, and ratio of T2 values. Correlation analysis with time from the onset was achieved using Pearson or Spearman correlation coefficient (ρ) test.
resultsForty-two patients were included. The strongest correlation with the time from onset was the difference in T2 relaxation times (ρ = 0.71; CI95% = [0.48; 0.85]), followed by the ratio (ρ = 0.65; CI95% = [0.37; 0.82]) and the absolute T2 relaxation time (ρ = 0.4; CI95% = [0.06; 0.66]), whereas the FLAIR rSI showed the weakest correlation (ρ = 0.18; CI95% = [- 0.16-0.51]).
conclusionsThe difference and ratio in T2 relaxation times were correlated with the onset time in stroke patients in the 4.5-h window. T2 mapping generated from synthetic MRI may become a relevant tool to select WUS patients with subtle FLAIR hyperintensities. Given that no definitive statement can be made about its usefulness in the 4.5-h windows, further study including patients with an onset time > 4.5 h is required. KEY POINTS: • The difference and ratio in T2 relaxation times are each individually correlated with the time from stroke onset in the 4.5-h window. • FLAIR rSI showed a poor correlation with the time from stroke onset. • T2 mapping, directly generated from synthetic MRI, may be a suitable quantitative marker to select safely WUS patients with subtle FLAIR hyperintensities for intravenous thrombolysis.
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